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Isolation and Excision of Murine Aorta; A Versatile Technique in the Study of Cardiovascular Disease
Published on: November 24, 2014
Adventures in cardiovascular research
1Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Department of Medicine, Harvard Medical School, Boston, MA 02115, USA. ebraunwald@partners.org
Circulation
|July 15, 2009
Summary
This review covers 58 years of clinical cardiovascular research, detailing advancements in valvular heart disease, hypertrophic cardiomyopathy, heart failure, and myocardial ischemia. It highlights technological evolution from pressure tracings to genetic technologies.
Area of Science:
- Cardiovascular Medicine
- Clinical Research
- Medical Technology
Background:
- The article reviews four decades of clinical cardiovascular research, focusing on valvular heart disease, hypertrophic cardiomyopathy, heart failure, and myocardial ischemia.
- It traces the author's personal journey and contributions within these fields, starting from an introduction to cardiovascular hemodynamics in 1951.
Observation:
- The author details the progression of knowledge and technological innovation in cardiovascular research over 58 years.
- Key technological shifts include the transition from invasive pressure tracings to advanced genetic technologies for drug development.
Findings:
- Significant advancements have been made in understanding and treating valvular heart disease, hypertrophic cardiomyopathy, heart failure, and myocardial ischemia.
- The evolution of research tools has dramatically enhanced the ability to investigate cardiovascular conditions and therapeutic interventions.
Implications:
- The review underscores the dynamic nature of clinical cardiovascular research and the impact of technological innovation.
- It offers insights into the rewards of a research career and provides a historical perspective on the field's development.
