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Related Concept Videos

Cleavage and Blastulation01:33

Cleavage and Blastulation

After a large-single-celled zygote is produced via fertilization, the process of cleavage occurs while zygotes travel through the uterine tube. Cleavage is a mitotic cell division that does not result in growth. With each round of successive cell division, daughter cells get increasingly smaller.
Zygotic Development And Stem Cell Formation01:10

Zygotic Development And Stem Cell Formation

The development of all multicellular organisms starts with the fusion of haploid cells called sperm and egg to form a diploid zygote. A zygote is a totipotent cell that can develop into a complete organism. The zygote undergoes cell division or cleavage to form an 8-cell mass. Until this stage, the cells are spherical, loosely attached, and remain totipotent. Totipotent cells are capable of developing both the embryonic and the extraembryonic tissues. However, as they continue to divide, they...
Fertilization01:38

Fertilization

During fertilization, an egg and sperm cell fuse to create a new diploid structure. In humans, the process occurs once the egg has been released from the ovary, and travels into the fallopian tubes. The process requires several key steps: 1) sperm present in the genital tract must locate the egg; 2) once there, sperm need to release enzymes to help them burrow through the protective zona pellucida of the egg; and 3) the membranes of a single sperm cell and egg must fuse, with the sperm...

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Related Experiment Video

Updated: Jun 21, 2026

Protocol for Human Blastoids Modeling Blastocyst Development and Implantation
12:09

Protocol for Human Blastoids Modeling Blastocyst Development and Implantation

Published on: August 10, 2022

A theoretical model for single blastocyst transfer.

A Teranishi1, A Kuwata, T Fumino

  • 1Advanced Fertility Center of Fuchu Nozomi, Fuchu-cho 2-1-3, Izumi, Osaka 594-0071, Japan. a_teranishi@nozomiclinic.com

Journal of Assisted Reproduction and Genetics
|July 15, 2009
PubMed
Summary
This summary is machine-generated.

Selecting embryos with a grade of 3BB or higher for single embryo transfer (SET) can significantly reduce multiple pregnancy rates in assisted reproductive technology (ART). This strategy maintains high pregnancy rates while improving patient safety.

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Last Updated: Jun 21, 2026

Protocol for Human Blastoids Modeling Blastocyst Development and Implantation
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Published on: August 10, 2022

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10:59

Human Blastocyst Biopsy and Vitrification

Published on: July 26, 2019

Establishment of an Embryo Implantation Model In Vitro
05:13

Establishment of an Embryo Implantation Model In Vitro

Published on: June 21, 2024

Area of Science:

  • Reproductive Medicine and Assisted Reproductive Technology (ART)
  • Embryology and In Vitro Fertilization (IVF)

Background:

  • Dual embryo transfer (DET) in ART is associated with high multiple pregnancy rates.
  • Embryo grading is a key factor in predicting ART outcomes.
  • Optimizing embryo selection for single embryo transfer (SET) is crucial for reducing risks.

Purpose of the Study:

  • To examine the relationship between embryo grade and ART outcomes.
  • To determine the effectiveness of SET versus DET in reducing multiple pregnancies based on embryo quality.
  • To establish criteria for assigning patients to SET using embryo grade and availability.

Main Methods:

  • Retrospective review of medical records from an IVF fertility center.
  • Analysis of data from 247 women undergoing day 5 DET after IVF/intracytoplasmic sperm injection.
  • Calculation of theoretical multiple pregnancy rates for SET based on embryo grade (≥3BB) and availability.

Main Results:

  • Embryo grade significantly impacts implantation and pregnancy rates.
  • DET resulted in a 39.9% clinical pregnancy rate and a 33.3% multiple pregnancy rate.
  • Theoretical SET with embryos graded ≥3BB showed a 35.8% pregnancy rate but only a 7.2% multiple pregnancy rate.

Conclusions:

  • Embryos with a grade of 3BB or higher are suitable candidates for SET.
  • Implementing SET based on embryo grade can substantially decrease multiple pregnancy rates.
  • This approach offers a strategy to improve ART safety and efficiency.