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Drug interactions

Alan Boobis1, Jean-Baptiste Watelet, Rhys Whomsley

  • 1Department of Experimental Medicine and Toxicology, Division of Medicine, Imperial College London, Hammersmith Campus, London. a.boobis@imperial.ac.uk

Drug Metabolism Reviews
|July 16, 2009
PubMed

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A drug interaction occurs when the concurrent use of another drug, food, or an external substance alters the pharmacological activity of a drug. This interaction can modify the action of the original drug, affecting its effectiveness and safety.Drug–food interactions are significant as they impact drug absorption, metabolism, and excretion. For example, grapefruit juice is a well-known disruptor of drug metabolism. It inhibits the cytochrome P450 3A4 enzyme, crucial for the metabolism of many...
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Drug-receptor interaction describes the binding of receptors by drugs, but not all drug-receptor interactions result in activation and tissue response. For instance, the binding of agonists activates the receptor to generate a cellular reaction, while antagonists bind to receptors without causing their activation.
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