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Surface modification of and selective protein attachment to a flexible microarray pattern using atmospheric plasma
Hyun-Uk Lee1, So-Young Park, Yoon-Hee Kang
1College of Nanoscience and Nanotechnology, Pusan National University, Busan, Republic of Korea.
Acta Biomaterialia
|July 18, 2009
Summary
Atmospheric pressure plasma treatment modified poly-ether sulfone (PES) film surfaces, enhancing protein adhesion. This technique is suitable for creating flexible, uniform biomolecular adhesive chips.
Area of Science:
- Materials Science
- Surface Chemistry
- Biomaterials Engineering
Background:
- Poly-ether sulfone (PES) films are widely used but require surface modification for specific biomolecular interactions.
- Controlling surface properties like hydrophobicity and hydrophilicity is crucial for biomaterial applications.
- Plasma treatment offers a versatile method for surface functionalization.
Purpose of the Study:
- To investigate the effect of atmospheric pressure plasma (AP) treatment with different reactive gases (Ar/H2 and Ar/O2) on PES film surface properties.
- To evaluate the potential of AP-treated PES films for fabricating protein adhesive chips.
- To determine if the plasma treatment can create well-defined patterned surfaces for selective biomolecular adhesion.
Main Methods:
- Poly-ether sulfone (PES) films were treated using atmospheric pressure plasma (AP) with Ar/H2 and Ar/O2 gas mixtures.
- Surface properties including roughness, surface energy, and chemical composition (oxygen content) were analyzed.
- Protein staining was performed on patterned PES films to assess biomolecular adhesion characteristics.
Main Results:
- AP treatment with Ar/H2 and Ar/O2 in series significantly increased surface roughness (approx. 120%) and surface energy (approx. 30%) compared to Ar/O2 treatment alone.
- Hydrophilic properties were enhanced, indicated by increased oxygen content (approx. 10%).
- Patterned PES films exhibited well-defined activated regions, demonstrating high selectivity and sensitivity for protein adhesion.
Conclusions:
- Atmospheric pressure plasma treatment effectively modifies PES film surfaces, enhancing their hydrophilic properties and surface energy.
- The developed method allows for the fabrication of flexible protein adhesive chips with uniform biomolecular adhesive properties.
- This technique shows promise for creating advanced biomaterials for diagnostic and therapeutic applications.
