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Type IV Collagen of Basal Lamina01:05

Type IV Collagen of Basal Lamina

Type IV collagen is a 400 nm long, network-forming collagen that acts as a barrier between the epithelial and endothelial cells. Type IV collagen  forms the backbone of the basement membrane by scaffolding with laminin, entactin, proteoglycans, and fibronectin. Apart from rendering structural support to the basement membrane, it also helps entail signaling potentials necessary for both pathological and physiological functions.
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Disorders of Hemostasis

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Chronic Salmonella Infection Induced Intestinal Fibrosis
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Haemorrhoids - a collagen disease?

S Willis1, K Junge, R Ebrahimi

  • 1Department of Surgery, Klinikum Ludwigshafen, Germany. williss@klilu.de

Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland
|July 21, 2009
PubMed
Summary

Patients with hemorrhoidal disease exhibit impaired collagen metabolism, showing significantly lower collagen quantity and quality compared to healthy individuals. This suggests a fundamental issue with collagen in hemorrhoids.

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Area of Science:

  • Gastroenterology and Surgery
  • Connective Tissue Biology

Background:

  • The etiology of hemorrhoidal disease remains unclear, but connective tissue integrity is implicated.
  • Reduced stability of connective tissue is hypothesized to contribute to hemorrhoid development.

Purpose of the Study:

  • To investigate collagen quantity and quality in the corpus cavernosum recti of patients with advanced hemorrhoidal disease.
  • To compare collagen parameters in hemorrhoid patients versus individuals without hemorrhoids.

Main Methods:

  • Analysis of hemorrhoidectomy specimens from 31 patients with III°/IV° hemorrhoids.
  • Comparison with 20 control specimens from individuals without hemorrhoidal disease.
  • Quantification of collagen via collagen/protein ratio and assessment of collagen quality using the collagen I/III ratio via cross-polarization spectroscopy.

Main Results:

  • Hemorrhoid patients displayed a significantly lower collagen/protein ratio (42.2 ± 16.2μg/mg) versus controls (72.5±31.0μg/mg; P=.02).
  • A significantly reduced collagen I/III ratio (2.0±0.1) was observed in hemorrhoid patients compared to controls (4.6±0.3; P<.001).
  • No correlation was found between these collagen parameters and patient age or gender.

Conclusions:

  • Patients with hemorrhoidal disease present with a fundamental disorder in collagen metabolism.
  • The underlying cause of this collagen disorder (exogenous or endogenous) requires further investigation.