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Related Concept Videos

Gastrointestinal Motility Disorders01:20

Gastrointestinal Motility Disorders

Gastrointestinal or GI motility disorders are characterized by irregular gastrointestinal tract movements, disrupting food transit from the mouth to the anus. They are caused by damage or dysfunction in gut muscles or nerves. These disorders can cause symptoms such as severe constipation, diarrhea, abdominal pain, and swallowing difficulties. Disorders can affect any segment of the GI tract and range widely in severity, from common conditions like GERD to life-threatening conditions like...
Drugs for Treatment of Constipation-Predominant IBS01:21

Drugs for Treatment of Constipation-Predominant IBS

Pharmacological therapies for IBS-C are designed to alleviate abdominal discomfort and enhance bowel function. In patients with IBS-C, fiber supplements may help soften stools and decrease straining, but may also lead to increased gas production and bloating. Osmotic laxatives like milk of magnesia are frequently used to soften stools and increase stool frequency in IBS-C patients. In addition, two drugs approved for use in severe IBS-C adult cases are linaclotide (Linzess) and lubiprostone...
Drugs Affecting GI Tract Motility: Serotonin Receptor Agonists01:23

Drugs Affecting GI Tract Motility: Serotonin Receptor Agonists

Serotonin, a crucial neurotransmitter synthesized by enterochromaffin cells, plays a cardinal role in regulating gastrointestinal (GI) motility. With over 90% of the body's total serotonin in the GI tract, its influence on digestive processes is profound. Serotonin is swiftly released upon various stimuli, such as food boluses or certain drugs, triggering intrinsic sensory neurons in the myenteric plexus and extrinsic vagal and spinal sensory neurons. This leads to the activation of the...
Drugs Affecting GI Tract Motility: Bulk-Forming and Stimulant Laxatives01:22

Drugs Affecting GI Tract Motility: Bulk-Forming and Stimulant Laxatives

Laxatives enhance bowel movements and alleviate constipation. They augment the stool's bulk, stimulate intestinal muscle contractions, draw water into the intestines, or soften the stool. There are five key types of laxatives: bulk laxatives, stimulant laxatives, osmotic laxatives, stool softeners, and lubricant laxatives.
Bulk-forming laxatives, such as psyllium, methylcellulose, and polycarbophil, absorb water in the intestine, increasing stool bulk and promoting bowel movement. This makes...
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Imaging Studies III: Gastrointestinal Motility Studies and Virtual Colonoscopy01:26

Imaging Studies III: Gastrointestinal Motility Studies and Virtual Colonoscopy

This lesson explores three gastrointestinal imaging techniques: radionuclide testing, colonic transit studies, and virtual colonoscopy.
Radionuclide Testing
Radionuclide testing is a sophisticated medical technique for assessing gastrointestinal motility. It focuses on gastric emptying and colonic transit time. Radioactive markers track the movement of food through the digestive system, providing insights into gastrointestinal disorders.
In gastric emptying studies, a meal's liquid and solid...

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Related Experiment Video

Updated: Jun 21, 2026

Studying Murine Small Bowel Mechanosensing of Luminal Particulates
10:21

Studying Murine Small Bowel Mechanosensing of Luminal Particulates

Published on: March 18, 2022

Small bowel motility in functional chronic constipation.

H Seidl1, F Gundling, C Pehl

  • 1Bogenhausen Academic Teaching Hospital, Department of Gastroenterology, Hepatology and Gastrointestinal Oncology, Munich, Germany.

Neurogastroenterology and Motility
|July 21, 2009
PubMed
Summary
This summary is machine-generated.

Small bowel motor abnormalities are common in slow-transit constipation (STC) and normal-transit constipation (NTC) but not outlet delay (OD). Prolonged jejunal manometry reveals underlying enteric neuropathy in STC and NTC, but lacks distinct features to differentiate them.

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Video Imaging and Spatiotemporal Maps to Analyze Gastrointestinal Motility in Mice
07:41

Video Imaging and Spatiotemporal Maps to Analyze Gastrointestinal Motility in Mice

Published on: February 3, 2016

Area of Science:

  • Gastroenterology
  • Digestive Physiology
  • Motility Disorders

Background:

  • Functional constipation comprises slow-transit constipation (STC), normal-transit constipation (NTC), and outlet delay (OD).
  • Extracolonic manifestations, particularly disturbed small bowel motility, are recognized in STC but less studied in NTC and OD.

Purpose of the Study:

  • To investigate small bowel motility using 24-hour ambulatory jejunal manometry in patients with chronic constipation subtypes.
  • To identify pathophysiological differences and potential underlying mechanisms, such as enteric neuropathy, across constipation types.

Main Methods:

  • Conducted 24-hour ambulatory jejunal manometry on 61 chronic constipation patients (STC, NTC, OD) after standardized meals.
  • Utilized transit-time studies, anorectal manometry, defecography, and colonoscopy for comprehensive patient assessment.
  • Compared manometric data with 50 healthy subjects, employing both computerized and visual analysis.

Main Results:

  • Small bowel motor abnormalities were observed in all STC (n=32) and 94% of NTC (n=16) patients, but none with OD (n=8).
  • Abnormalities included severe disruptions (loss of migrating motor complex) and subtle parameter changes, detectable by computerized analysis.
  • No significant manometric differences were found between STC and NTC patients, suggesting a common underlying enteric neuropathy.

Conclusions:

  • 24-hour ambulatory jejunal manometry provides valuable insights into the pathophysiology of STC and NTC functional constipation.
  • Findings strongly suggest an underlying enteric neuropathy in both STC and NTC, though distinct manometric features are lacking for differentiation.