Related Experiment Videos

C-reactive protein predicts long-term mortality independently of low-density lipoprotein cholesterol in patients

Louai Razzouk1, Paul Muntner, Sameer Bansilal

  • 1Cardiac Catheterization Laboratory and Clinical Trials Unit, Cardiovascular Institute, Mount Sinai Heart, New York, NY, USA.

American Heart Journal
|July 22, 2009
PubMed

Insights

High-sensitivity C-reactive protein (hs-CRP) levels independently predict mortality risk in patients after percutaneous coronary intervention (PCI). Elevated hs-CRP significantly increases the risk of death, even when low-density lipoprotein cholesterol levels are considered.

Area of Science:

  • Cardiology
  • Biomarkers
  • Public Health

Background:

  • Limited data exist on the association between high-sensitivity C-reactive protein (hs-CRP) and mortality in patients undergoing percutaneous coronary intervention (PCI), independent of low-density lipoprotein (LDL) cholesterol.
  • hs-CRP is an inflammatory marker, and its role in predicting outcomes post-PCI warrants further investigation.

Purpose of the Study:

  • To investigate the independent prognostic value of hs-CRP levels for all-cause mortality in patients after PCI.
  • To determine if hs-CRP provides additional predictive information beyond LDL cholesterol levels.

Main Methods:

  • A cohort of 8,834 patients undergoing PCI between 2002 and 2006 was followed up to 2007.
  • hs-CRP levels were categorized into four groups: <1.0, 1.0-2.9, 3.0-9.9, and ≥10 mg/L.
  • Multivariable analysis, including LDL cholesterol, was used to assess the association between hs-CRP and all-cause mortality.

Main Results:

  • All-cause mortality rates increased significantly with higher hs-CRP levels, ranging from 14.4 to 56.4 per 1,000 person-years.
  • After adjusting for LDL cholesterol and other factors, hs-CRP levels of 3.0-9.9 mg/L and ≥10 mg/L were associated with significantly higher mortality risk (HR 1.70 and 2.99, respectively).
  • These trends persisted across different LDL cholesterol strata, and no significant interaction was found between hs-CRP and LDL cholesterol for mortality prediction.

Conclusions:

  • hs-CRP levels offer significant incremental prognostic information for predicting all-cause mortality in patients post-PCI during long-term follow-up.
  • hs-CRP is a valuable independent predictor of mortality, providing crucial information beyond LDL cholesterol levels in this patient population.
Abstract

Related Concept Videos

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
Coronary Artery Disease IV: Preventive Measures01:26

Coronary Artery Disease IV: Preventive Measures

Effective preventive measures for coronary artery disease (CAD) focus on controlling modifiable risk factors, including cholesterol abnormalities and lifestyle changes.Cholesterol ManagementFirst, the Mediterranean diet and the American Heart Association advocate for maintaining low-density lipoprotein (LDL) cholesterol levels below 100 mg/dL, with a more stringent recommendation of below 70 mg/dL for individuals at high risk. LDL cholesterol, often termed "bad cholesterol," can lead to the...
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT01:25

Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT

Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...