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Analysis of 18FDG PET/CT Imaging as a Tool for Studying Mycobacterium tuberculosis Infection and Treatment in Non-human Primates
Published on: September 5, 2017
Morphological spectrum of gastrointestinal tuberculosis
Prachi B Tripathi1, Anjali D Amarapurkar
1Department of Pathology, T.N. Medical College & BYL Nair Charitable Hospital, Mumbai, India.
Tropical Gastroenterology : Official Journal of the Digestive Diseases Foundation
|July 24, 2009
Summary
Gastrointestinal tuberculosis (GITB) presents diverse gross and microscopic features, including frequent intestinal perforation. Awareness of this spectrum is crucial for accurate pathological diagnosis, preventing misclassification with other inflammatory conditions.
Area of Science:
- Gastroenterology
- Pathology
- Infectious Diseases
Background:
- Gastrointestinal tuberculosis (GITB) is challenging to differentiate from other intestinal inflammatory conditions due to its varied presentation.
- Accurate diagnosis of GITB is essential for appropriate patient management.
Purpose of the Study:
- To comprehensively analyze the full range of gross and histopathological characteristics of gastrointestinal tuberculosis.
Main Methods:
- Study included 110 diagnosed GITB cases.
- Diagnosis confirmed by acid-fast bacilli (AFB) on histology, epithelioid cell granulomas (ECGs), extraintestinal tuberculosis evidence, and response to anti-tuberculous treatment (ATT).
Main Results:
- Intestinal perforation (32.6%) and ischemic bowel (7.3%) were noted alongside typical tuberculous lesions.
- Histopathology revealed diverse ECG patterns (caseating, non-caseating, confluent, discrete, suppurative), often coexisting within the same case.
- Granulomas frequently occurred in the submucosa (44.5%), with lymphoplasmacytic inflammation predominant in the lamina propria (85.5%).
Conclusions:
- Pathologists must recognize the broad spectrum of GITB's gross and histopathological findings.
- Increased awareness can prevent misdiagnosis of GITB as other intestinal inflammatory lesions.
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