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Related Experiment Videos

[Renal function in children with solitary kidney].

R Konda1, S Orikasa, K Sakai

  • 1Department of Urology, Tohoku University School of Medicine.

Nihon Hinyokika Gakkai Zasshi. the Japanese Journal of Urology
|November 1, 1990
PubMed
Summary

Children with a solitary kidney often experience renal overload early in life, even without other urinary tract anomalies. This study assessed kidney function using DMSA scans and urinary markers.

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Area of Science:

  • Pediatric Nephrology
  • Renal Physiology
  • Diagnostic Biomarkers

Context:

  • Solitary kidney presents unique challenges in pediatric renal health.
  • Assessing renal function in children with solitary kidneys is crucial for early intervention.
  • Previous studies highlight the importance of monitoring kidney function in these patients.

Purpose:

  • To evaluate renal function in children with solitary kidneys using Dimercaptosuccinic acid (DMSA) renal uptake and urinary biomarkers.
  • To identify early signs of renal overload in children with solitary kidneys, irrespective of associated anomalies.
  • To correlate DMSA uptake rates with urinary excretion of alpha-1-microglobulin (alpha 1-MG), beta-2-microglobulin (beta 2-MG), N-acetyl-beta-D-glucosaminidase (NAG), and microalbumin.

Summary:

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  • Eighteen children with solitary kidneys (14 congenital, 4 acquired) underwent assessment.
  • DMSA renal uptake was reduced in 10 children, with 5 showing uptake less than 70% of controls.
  • Elevated urinary alpha 1-MG and microalbumin were observed in several children, often correlating with low DMSA uptake, even in those without other anomalies.

    • Impact:

    • Findings suggest that renal overload can develop early in children with solitary kidneys, even without apparent urinary tract abnormalities.
    • Early detection of renal overload through DMSA and urinary markers is vital for managing solitary kidney patients.
    • This research underscores the need for vigilant monitoring of renal function in pediatric solitary kidney cases to prevent long-term complications.