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Updated: Jun 21, 2026

Caffeine Extraction, Enzymatic Activity and Gene Expression of Caffeine Synthase from Plant Cell Suspensions
Published on: October 2, 2018
[Coffee, its legend, history, and influence on human health]
H Tesfaye1, J Blahos, J Janatová
1Univerzita Karlova v Praze, 2. lékarská fakulta, Ustav klinické biochemie a patobiochemie, oddelení klinické farmakologie FN Motol, Praha. hundie.tesfaye@fnmotol.cz
Abstract:
In the introductory part of this article the history/legend of coffee as well as its spread to different parts of the world including Europe is discussed. Data sofar available in literature do not give any convincing evidence regarding clear relationship between coffee and the etiopathogenesis of several diseases including diabetes mellitus type 2, cardiovascular diseases, gout, osteoporosis, neurologic disorders and colorectal cancer. Favorable (protective) effects of coffee consumption against hepatocellular cancer have been repeatedly described. The autors discuss on todate findings about relationship between blood cholesterol and uric acid in literature and remind their own experience with different population groups in Harar, Ethiopia, where consumption of coffee is habitual in daily life of the inhabitants.
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