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Updated: Jun 21, 2026

Multimodal Approach to Assess Bone Regeneration and Scaffold Performance
Published on: February 13, 2026
The use of microtomography in bone tissue and biomaterial three-dimensional analysis
Rossella Bedini1, Deborah Meleo, Raffaella Pecci
1Dipartimento di Tecnologie e Salute, Istituto Superiore di Sanità, Rome, Italy. rossella.bedini@iss.it
Abstract:
X-ray computed microtomography (micro-CT, microComputerised Tomography) is a miniaturized form of conventional computerized axial tomography (CAT ). This sophisticated technology enables 3D riconstruction of the internal structure of small X-ray opaque objects without sample destruction or preparation. The aim of this study is to show the possible applications of micro-CT in the analysis of bone graft materials of different origins (i.e. homologous, heterologous, alloplastic) in order to define their morphometric properties by means of SkyScan 1072 3D microtomography system. Since there is a close relationship between the properties of the materials and their microstructure, it is necessary to examine them using the highest levels of resolution before being able to improve existing materials or create new products.
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