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Updated: Jun 21, 2026

Measuring Psoriasis Severity at Home
Published on: March 1, 2024
Genetic susceptibility to psoriasis: an emerging picture
Rhodri Ll Smith1, Richard B Warren, Christopher Em Griffiths
1ARC Epidemiology Unit, University of Manchester, Manchester, M13 9PT, UK.
Abstract:
Psoriasis is recognized as a complex disease for which multiple genetic and non-genetic factors influence susceptibility. The major susceptibility locus resides in the MHC class I region and, until relatively recently, evidence for non-MHC loci was inconsistent. Like many common diseases, knowledge of the genetic basis of this condition has been advanced dramatically in recent times with the advent of genome-wide association studies using single nucleotide polymorphisms. Here, we give an overview of current knowledge of genetic risk factors for psoriasis and consider emerging studies that may further add to our understanding of the genetic basis of the disease.
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