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Published on: August 25, 2021
Dynamic advances in NF-kappaB signaling analysis
Taeko Kobayashi1, Ryoichiro Kageyama
1Institute for Virus Research, Kyoto University, Shogoin-Kawahara, Sakyo-ku; Japan Science and Technology Agency, CREST, Kyoto 606-8507, Japan. tkobayas@virus.kyoto-u.ac.jp
Abstract:
Signaling through the transcription factor nuclear factor kappaB (NF-kappaB) regulates various physiological processes, including immune responses and inflammation. An analysis of NF-kappaB dynamics suggests that the oscillation frequency of NF-kappaB activation determines which downstream genes are expressed, enabling a single pathway to respond to diverse stimuli in distinct ways.
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