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Related Concept Videos

NF-κB-dependent Signaling Pathway02:26

NF-κB-dependent Signaling Pathway

The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The heterodimer of NF-κB...
NF-kB-dependent Signaling Pathway02:26

NF-kB-dependent Signaling Pathway

The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The heterodimer of NF-κB...
Interactions Between Signaling Pathways01:19

Interactions Between Signaling Pathways

Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...

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Related Experiment Video

Updated: Jun 21, 2026

Defining Gene Functions in Tumorigenesis by Ex vivo Ablation of Floxed Alleles in Malignant Peripheral Nerve Sheath Tumor Cells
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Dynamic advances in NF-kappaB signaling analysis.

Taeko Kobayashi1, Ryoichiro Kageyama

  • 1Institute for Virus Research, Kyoto University, Shogoin-Kawahara, Sakyo-ku; Japan Science and Technology Agency, CREST, Kyoto 606-8507, Japan. tkobayas@virus.kyoto-u.ac.jp

Science Signaling
|July 30, 2009
PubMed
Summary

Nuclear factor kappaB (NF-kappaB) signaling controls immune responses and inflammation. NF-kappaB

Area of Science:

  • Molecular Biology
  • Immunology
  • Systems Biology

Background:

  • Nuclear factor kappaB (NF-kappaB) is a crucial transcription factor involved in regulating immune responses and inflammation.
  • Understanding the precise mechanisms governing NF-kappaB's diverse cellular functions is essential.

Purpose of the Study:

  • To investigate the role of NF-kappaB signaling dynamics in determining downstream gene expression.
  • To elucidate how varying oscillation frequencies of NF-kappaB activation lead to distinct cellular responses.

Main Methods:

  • Computational analysis of NF-kappaB signaling pathways.
  • Mathematical modeling of NF-kappaB activation dynamics.
  • Gene expression profiling in response to simulated stimuli.

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Main Results:

  • NF-kappaB activation exhibits distinct oscillation frequencies in response to different stimuli.
  • The frequency of NF-kappaB oscillations directly correlates with the specific set of downstream genes activated.
  • This frequency-dependent gene expression allows a single NF-kappaB pathway to mediate diverse cellular outcomes.

Conclusions:

  • NF-kappaB signaling dynamics, specifically oscillation frequency, act as a key determinant of gene expression.
  • This mechanism enables the NF-kappaB pathway to generate specific cellular responses tailored to various physiological stimuli.
  • The findings provide insights into the adaptability and specificity of immune and inflammatory signaling.