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Related Experiment Video

Updated: Jun 21, 2026

Combination of Microstereolithography and Electrospinning to Produce Membranes Equipped with Niches for Corneal Regeneration

Combination of Microstereolithography and Electrospinning to Produce Membranes Equipped with Niches for Corneal Regeneration

Published on: September 12, 2014

[Stem cell therapy for corneal defects].

A Schilimow¹, B Wiechens

¹Klinik für Augenheilkunde, Klinikum Region Hannover, Klinikum Nordstadt.

Klinische Monatsblatter Fur Augenheilkunde

|August 1, 2009

Summary

This summary is machine-generated.

Limbus stem cell transplantation is a key treatment for corneal defects. Other stem cells like epithelial, epidermal, and mesenchymal cells also promote corneal regeneration and healing.

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Last Updated: Jun 21, 2026

Combination of Microstereolithography and Electrospinning to Produce Membranes Equipped with Niches for Corneal Regeneration

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Published on: September 12, 2014

Isolation and Identification of Limbal Niche Cells

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Adenoviral Gene Therapy for Diabetic Keratopathy: Effects on Wound Healing and Stem Cell Marker Expression in Human Organ-cultured Corneas and Limbal Epithelial Cells

Adenoviral Gene Therapy for Diabetic Keratopathy: Effects on Wound Healing and Stem Cell Marker Expression in Human Organ-cultured Corneas and Limbal Epithelial Cells

Published on: April 7, 2016

Area of Science:

Ophthalmology
Regenerative Medicine
Stem Cell Biology

Context:

Corneal defect healing relies on limbus stem cells.
Loss of limbus stem cells causes wound healing complications.
Stem cell research presents novel therapeutic strategies for corneal regeneration.

Purpose:

To review current and experimental stem cell therapies for corneal defects.
To highlight the role of various stem cell types in corneal repair.
To discuss the potential of stem cell transplantation in ophthalmology.

Summary:

Autologous limbus stem cell transplantation is the primary treatment for corneal defects.
Amniotic membrane transplantation with limbus stem cells is clinically validated.
Experimental approaches include bone marrow-derived mesenchymal stem cells, epidermal stem cells, and adipose-derived stem cells for corneal healing.
In vitro cultivated buccal mucosa epithelial cell transplantation has also been clinically tested.

Impact:

Limbus stem cell failure limits autologous transplantation success.
Epithelial, epidermal, and mesenchymal stem cells (bone marrow- or adipose-derived) are established treatments for corneal defects.
Mesenchymal stem cells provide immunosuppressive and anti-inflammatory benefits, enhancing their therapeutic potential.