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Related Experiment Video

Updated: Jun 21, 2026

Experimental Protocol for Examining Behavioral Response Profiles in Larval Fish: Application to the Neuro-stimulant Caffeine

Experimental Protocol for Examining Behavioral Response Profiles in Larval Fish: Application to the Neuro-stimulant Caffeine

Published on: July 24, 2018

Caffeine, cycling performance, and exogenous CHO oxidation: a dose-response study.

Ben Desbrow¹, Clare M Barrett, Clare L Minahan

¹School of Public Health, Griffith University, Queensland, Australia. b.desbrow@griffith.edu.au

Medicine and Science in Sports and Exercise

|August 7, 2009

Summary

Caffeine did not improve endurance performance or carbohydrate oxidation in trained cyclists. These findings suggest that low to moderate caffeine doses are ineffective for enhancing athletic capacity in fed individuals.

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Bioenergetic Profile Experiment using C2C12 Myoblast Cells

Published on: December 6, 2010

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Last Updated: Jun 21, 2026

Experimental Protocol for Examining Behavioral Response Profiles in Larval Fish: Application to the Neuro-stimulant Caffeine

Experimental Protocol for Examining Behavioral Response Profiles in Larval Fish: Application to the Neuro-stimulant Caffeine

Published on: July 24, 2018

Bioenergetic Profile Experiment using C2C12 Myoblast Cells

Published on: December 6, 2010

Area of Science:

Sports Science and Exercise Physiology
Nutritional Biochemistry

Background:

Caffeine is a widely used ergogenic aid known to potentially enhance endurance exercise performance.
Its effects on exogenous carbohydrate (CHO) oxidation and performance in trained athletes, particularly in a fed state, require further investigation.

Purpose of the Study:

To investigate the impact of low (1.5 mg/kg BW) and moderate (3 mg/kg BW) caffeine doses on exogenous CHO oxidation.
To assess the effects of these caffeine doses on endurance-exercise performance in trained male cyclists.

Main Methods:

Nine trained male cyclists completed three double-blind, placebo-controlled trials.
Subjects ingested placebo or caffeine (1.5 or 3 mg/kg BW) one hour before a 120-minute steady-state cycling bout followed by a time trial.
Exogenous CHO oxidation was measured using C-glucose during exercise.

Main Results:

No significant improvements in time trial performance were observed with either caffeine dose compared to placebo.
Caffeine administration did not significantly alter maximal exogenous CHO oxidation rates.
Individual performance times showed variability, but group means were not statistically different.

Conclusions:

Low and moderate doses of caffeine do not enhance endurance exercise performance in fed, trained cyclists.
Caffeine does not significantly affect exogenous carbohydrate oxidation under these specific exercise conditions.
The ergogenic potential of caffeine may be context-dependent, with factors like feeding status influencing outcomes.