Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Harnessing Membrane-Active Peptides for Selective Cancer Targeting: Phosphatidylserine Recognition by Tilapia Piscidin 4.

JACS Au·2026
Same author

Logarithmic Binding and Stretched-Exponential Kinetics in Peripheral Protein Interactions with Lipid Membrane Surfaces.

The journal of physical chemistry letters·2026
Same author

AI-driven antimicrobial peptide characterization unveils novel motifs for drug design.

Scientific reports·2025
Same author

Poly-Arginine Tails and Helical Segments of Natural Antimicrobial Peptides Display Concerted Action at Membranes for Enhanced Antimicrobial Effects.

ACS bio & med chem Au·2025
Same author

Global and local effects in lipid-mediated interactions between peripheral and integral membrane proteins.

Frontiers in molecular biosciences·2025
Same author

<i>AutoRefl</i>: active learning in neutron reflectometry for fast data acquisition.

Journal of applied crystallography·2025
Same journal

Erratum: Bacterial Turbulence at Compressible Fluid Interfaces [Phys. Rev. Lett. 136, 138301 (2026)].

Physical review letters·2026
Same journal

Unveiling Light-Quark Yukawa Flavor Structure via Dihadron Fragmentation at Lepton Colliders.

Physical review letters·2026
Same journal

Adaptable Route to Fast Coherent State Transport via Bang-Bang-Bang Protocols.

Physical review letters·2026
Same journal

Topological Transition and Emergence of Elasticity of Dislocation in Skyrmion Lattice: Beyond Kittel's Magnetic-Polar Analogy.

Physical review letters·2026
Same journal

Pound-Drever-Hall Method for Superconducting-Qubit Readout.

Physical review letters·2026
Same journal

Coupling a ^{73}Ge Nuclear Spin to an Electrostatically Defined Quantum Dot in Silicon.

Physical review letters·2026
See all related articles

Related Experiment Video

Updated: Jun 21, 2026

Monitoring Protein Adsorption with Solid-state Nanopores
08:51

Monitoring Protein Adsorption with Solid-state Nanopores

Published on: December 2, 2011

Probing surface charge fluctuations with solid-state nanopores.

David P Hoogerheide1, Slaven Garaj, Jene A Golovchenko

  • 1Physics Department, Harvard University, Cambridge Massachusetts 02138, USA.

Physical Review Letters
|August 8, 2009
PubMed
Summary
This summary is machine-generated.

Excess ionic current noise in solid-state nanopores originates from surface charge fluctuations. This noise can be minimized by optimizing nanopore pH, crucial for sensitive measurements.

More Related Videos

Fine-tuning the Size and Minimizing the Noise of Solid-state Nanopores
09:43

Fine-tuning the Size and Minimizing the Noise of Solid-state Nanopores

Published on: October 31, 2013

Scanning-probe Single-electron Capacitance Spectroscopy
10:53

Scanning-probe Single-electron Capacitance Spectroscopy

Published on: July 30, 2013

Related Experiment Videos

Last Updated: Jun 21, 2026

Monitoring Protein Adsorption with Solid-state Nanopores
08:51

Monitoring Protein Adsorption with Solid-state Nanopores

Published on: December 2, 2011

Fine-tuning the Size and Minimizing the Noise of Solid-state Nanopores
09:43

Fine-tuning the Size and Minimizing the Noise of Solid-state Nanopores

Published on: October 31, 2013

Scanning-probe Single-electron Capacitance Spectroscopy
10:53

Scanning-probe Single-electron Capacitance Spectroscopy

Published on: July 30, 2013

Area of Science:

  • Nanotechnology
  • Physical Chemistry
  • Electrochemistry

Background:

  • Solid-state nanopores are crucial for sensing applications.
  • Ionic current noise can limit nanopore device sensitivity.
  • Understanding noise sources is vital for improving nanopore performance.

Purpose of the Study:

  • To identify and characterize the dominant noise source in solid-state nanopores.
  • To investigate the origins of excess ionic current noise.
  • To develop a model for predicting and mitigating nanopore noise.

Main Methods:

  • Experimental measurement of ionic current noise spectra.
  • Systematic variation of pH and electrolyte concentration.
  • Development of a quantitative model based on surface protonization.

Main Results:

  • A significant excess noise component was identified in the 0.1-10 kHz range.
  • Noise dependence on pH and concentration points to surface charge fluctuations.
  • The protonization model accurately predicts experimental observations.
  • Protonization reaction rates were quantitatively measured.

Conclusions:

  • Surface charge fluctuations due to protonization are a major noise contributor in nanopores.
  • Nanopore noise can be minimized by selecting an optimal operating pH.
  • This work provides a method for in-situ measurement of surface reaction kinetics.