Related Experiment Video
Updated: Jun 21, 2026
02:28
Measuring Psoriasis Severity at Home
Published on: March 1, 2024
Established psoriatic arthritis: clinical aspects.
1Academic Unit of Musculoskeletal and Rehabilitation Medicine, University of Leeds, Leeds, LS7 4SA, UK. p.helliwell@leeds.ac.uk
The Journal of Rheumatology. Supplement
|August 8, 2009
Summary
Psoriatic arthritis (PsA) remains heterogeneous, with ongoing debate on classification and subgroups. New data clarify dactylitis as a severity marker and highlight differences in spinal disease compared to ankylosing spondylitis.
Area of Science:
- Rheumatology and immunology
- Clinical research in musculoskeletal diseases
Background:
- Psoriatic arthritis (PsA) is a complex, heterogeneous inflammatory disease.
- Classification criteria and subgroup analysis for PsA are subjects of ongoing debate within the rheumatology community.
- The hallmark "Moll and Wright" publication from 35 years ago continues to influence current understanding and research.
Purpose of the Study:
- To review current understanding and recent data on psoriatic arthritis (PsA).
- To address ongoing debates regarding classification criteria and subgroup definitions in PsA.
- To explore key manifestations like dactylitis, enthesitis, and spinal disease in PsA.
Main Methods:
- Review of historical archives and recent data on PsA manifestations.
- Analysis of findings from the CASPAR study for defining arthritis mutilans.
- Comparison of spinal disease in PsA with ankylosing spondylitis, including development of a new scoring system.
Main Results:
- Dactylitis is identified as a significant marker of disease severity in PsA.
- Enthesitis in PsA shows a poor correlation between clinical assessment and ultrasonographic findings.
- Spinal disease in PsA differs from ankylosing spondylitis, leading to a new modified scoring index.
Conclusions:
- Further research is needed to refine PsA classification and subgroup definitions.
- Understanding specific manifestations like dactylitis and enthesitis is crucial for managing PsA.
- New tools are being developed to better characterize spinal involvement in PsA.
Related Concept Videos
01:21Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation
Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
01:22Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies
The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
01:27Atherosclerosis II: Clinical Manifestations and Diagnostic Tests
Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
01:20Inflammatory Bowel Disease IV: Clinical Manifestations
Inflammatory bowel disease (IBD) encompasses two major chronic disorders—ulcerative colitis and Crohn’s disease—each characterized by relapsing episodes of gastrointestinal inflammation. Although they share certain clinical features, their patterns of involvement and manifestations differ in ways that aid diagnosis and guide management.Ulcerative ColitisUlcerative colitis is limited to the colon and rectum and involves continuous inflammation of the mucosal layer. The disease course is marked...
01:20COPD: Pathogenesis and Clinical Features
Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
01:30Peripheral Artery Disease I: Introduction
Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...