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07:37
An Adoptive Transfer Model of Rheumatoid Arthritis in Mice
Published on: June 6, 2025
Translational perspectives on psoriatic arthritis
Christopher T Ritchlin1, Steven Proulx, Edward S Schwarz
1University of Rochester Medical Center, Rochester, New York, USA. christopher_ritchlin@urmc.rochester.edu
The Journal of Rheumatology. Supplement
|August 8, 2009
Summary
Psoriatic disease involves multiple conditions linked to psoriasis. Elevated osteoclast precursors (OCP) may indicate arthritis risk and bone destruction in psoriasis patients.
Area of Science:
- Immunodermatology
- Rheumatology
- Translational Medicine
Background:
- Psoriatic disease includes psoriasis and associated conditions like psoriatic arthritis (PsA).
- Osteoclast precursors (OCP) are elevated in PsA and correlate with bone destruction.
- OCP are also increased in early rheumatoid arthritis and some psoriasis patients without arthritis.
Purpose of the Study:
- Investigate potential biomarkers for arthritis in psoriasis patients.
- Explore early indicators of joint inflammation and flare in psoriatic disease.
Main Methods:
- Review of previous studies on osteoclast precursors (OCP) in psoriatic arthritis (PsA).
- Analysis of findings from transgenic tumor necrosis factor (TNF) arthritis murine models.
- Correlation of OCP frequency with bone destruction and imaging findings.
Main Results:
- Osteoclast precursors (OCP) are elevated in psoriatic arthritis (PsA) and correlate with bone destruction.
- Increased OCP levels are observed in early rheumatoid arthritis and psoriasis patients without arthritis.
- Studies in TNF transgenic mouse models show lymph node volume changes precede joint flares.
Conclusions:
- Elevated OCP may serve as a biomarker for arthritis development in psoriasis.
- Inflammatory cell infiltration in bone marrow and lymph node changes precede joint flare.
- These findings offer insights into early events driving arthritic flare in psoriatic disease.
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