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Related Concept Videos

Cooperative Allosteric Transitions01:58

Cooperative Allosteric Transitions

Cooperative allosteric transitions can occur in multimeric proteins, where each subunit of the protein has its own ligand-binding site. When a ligand binds to any of these subunits, it triggers a conformational change that affects the binding sites in the other subunits; this can change the affinity of the other sites for their respective ligands. The ability of the protein to change the shape of its binding site is attributed to the presence of a mix of flexible and stable segments in the...
Cooperative Allosteric Transitions01:58

Cooperative Allosteric Transitions

Cooperative allosteric transitions can occur in multimeric proteins, where each subunit of the protein has its own ligand-binding site. When a ligand binds to any of these subunits, it triggers a conformational change that affects the binding sites in the other subunits; this can change the affinity of the other sites for their respective ligands. The ability of the protein to change the shape of its binding site is attributed to the presence of a mix of flexible and stable segments in the...
Cooperative Allosteric Transitions01:58

Cooperative Allosteric Transitions

Cooperative allosteric transitions can occur in multimeric proteins, where each subunit of the protein has its own ligand-binding site. When a ligand binds to any of these subunits, it triggers a conformational change that affects the binding sites in the other subunits; this can change the affinity of the other sites for their respective ligands. The ability of the protein to change the shape of its binding site is attributed to the presence of a mix of flexible and stable segments in the...
Valence Bond Theory02:42

Valence Bond Theory

Coordination compounds and complexes exhibit different colors, geometries, and magnetic behavior, depending on the metal atom/ion and ligands from which they are composed. In an attempt to explain the bonding and structure of coordination complexes, Linus Pauling proposed the valence bond theory, or VBT, using the concepts of hybridization and the overlapping of the atomic orbitals. According to VBT, the central metal atom or ion (Lewis acid) hybridizes to provide empty orbitals of suitable...
Valence Bond Theory02:45

Valence Bond Theory

Overview of Valence Bond Theory
¹H NMR: Long-Range Coupling01:27

¹H NMR: Long-Range Coupling

The coupling interactions of nuclei across four or more bonds are usually weak, with J values less than 1 Hz. While these are usually not observed in spectra, the presence of multiple bonds along the coupling pathway can result in observable long-range coupling.
In alkenes, spin information is communicated via σ–π overlap, as seen in allylic (four-bond) and homoallylic (five-bond) couplings. These coupling interactions are stronger when the σ bond is parallel to the alkene π orbitals.

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Preparation of SNS Cobalt(II) Pincer Model Complexes of Liver Alcohol Dehydrogenase
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Published on: March 19, 2020

Cooperativity in multiply H-bonded complexes.

Christopher A Hunter1, Ndidi Ihekwaba, Maria Cristina Misuraca

  • 1Department of Chemistry, University of Sheffield, Sheffield, UK. c.hunter@shef.ac.uk

Chemical Communications (Cambridge, England)
|August 8, 2009
PubMed
Summary
This summary is machine-generated.

The complexation free energy of supramolecular complexes with phenol-carbamate hydrogen bonds is additive. Each hydrogen bond contributes a constant 6 kJ mol(-1) increment in carbon tetrachloride.

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Area of Science:

  • Supramolecular Chemistry
  • Physical Chemistry

Background:

  • Hydrogen bonding is crucial in molecular recognition and self-assembly.
  • Quantifying the energetic contributions of specific interactions is key to understanding complexation behavior.

Purpose of the Study:

  • To determine the energetic contribution of phenol-carbamate hydrogen bonds to complexation free energy.
  • To investigate the additivity of hydrogen bond interactions in supramolecular complexes.

Main Methods:

  • Supramolecular complexation studies in carbon tetrachloride.
  • Thermodynamic analysis of binding equilibria.

Main Results:

  • The free energy of complexation is an additive function of the number of phenol-carbamate hydrogen bonds.
  • A constant increment of 6 kJ mol(-1) per hydrogen bond interaction was observed.

Conclusions:

  • Phenol-carbamate hydrogen bonds provide a predictable energetic contribution to supramolecular complexation.
  • This additivity simplifies the prediction and design of supramolecular systems based on hydrogen bonding.