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Updated: Jun 21, 2026
03:37
Cerebral Ischemic Coma Model Induced by Modified Four-Vessel Occlusion
Published on: July 5, 2024
[Deep non-reactive reversible coma after a Mediterranean neurotoxic fish poisoning]
1Service de neurologie, Hôtel-Dieu de France, Achrafieh, Beyrouth, Liban. awadaadnan@yahoo.com
Revue Neurologique
|August 12, 2009
Summary
A case of deep coma in an 80-year-old man was linked to eating toxic fish gonads. Prompt supportive care led to a full recovery, highlighting the dangers of tetrodotoxin poisoning.
Area of Science:
- Marine Biology
- Neuroscience
- Toxicology
Background:
- Neurotoxic fish poisoning is an emerging concern in the Mediterranean Sea.
- The pufferfish Lagocephalus scleratus, known to contain tetrodotoxin, has recently appeared in Mediterranean waters.
Observation:
- An 80-year-old male presented with rapid neurological decline, including coma, after consuming fish gonads.
- Symptoms progressed to quadriparesis, respiratory, and hemodynamic failure, with loss of brainstem reflexes.
Findings:
- The patient's symptoms were attributed to tetrodotoxin (TTX) poisoning from ingesting Lagocephalus scleratus gonads.
- Tetrodotoxin blocks voltage-gated sodium channels, inhibiting action potential propagation.
Implications:
- This case highlights the potential neurotoxic risks associated with the migration of exotic fish species into new marine environments.
- Intensive supportive treatment is crucial for managing tetrodotoxin poisoning, as no specific antidote exists.
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