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Phenotypic determinants of uncontrolled asthma.
Valérie Siroux1, Anne Boudier, Jean Bousquet
1INSERM, Institut National de la Santé et de la Recherche Médicale, U823, Institut Albert Bonniot, Grenoble, France. valerie.siroux@ujf-grenoble.fr
The Journal of Allergy and Clinical Immunology
|August 12, 2009
Summary
Asthma control is often poor, with different factors affecting it in inhaled corticosteroid (ICS) users versus non-users. Chronic cough and female sex were linked to uncontrolled asthma in ICS users, while high IgE and mold sensitization were factors in non-users.
Area of Science:
- Pulmonary Medicine
- Epidemiology
- Allergy & Immunology
Background:
- Uncontrolled asthma is a common issue, yet its determinants are not well understood.
- The Epidemiological study on the Genetics and Environment of Asthma (EGEA) investigated asthma control factors.
- Asthma control assessment is crucial for effective patient management.
Purpose of the Study:
- To determine the distribution and phenotypic characteristics of asthma control.
- To compare asthma control between inhaled corticosteroid (ICS) users and non-users.
- To identify factors associated with uncontrolled asthma in different patient groups.
Main Methods:
- 501 adult asthma patients from the EGEA study follow-up were analyzed.
- Asthma control was assessed using 2006 Global Initiative for Asthma guidelines criteria.
- Factors examined included demographics, lifestyle, atopy, and comorbidities, stratified by ICS use.
Main Results:
- Uncontrolled asthma was more prevalent in ICS users (37.4%) than non-users (16.1%).
- In ICS users, chronic cough/phlegm and female sex were linked to uncontrolled asthma.
- In non-ICS users, high total IgE and mold sensitization were associated with uncontrolled asthma.
Conclusions:
- Optimal asthma control is not achieved by most patients in this cohort.
- Factors influencing uncontrolled asthma differ significantly between ICS users and non-users.
- Targeted interventions based on ICS use may improve asthma control.
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