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Updated: Jun 21, 2026

Tracking the Mammary Architectural Features and Detecting Breast Cancer with Magnetic Resonance Diffusion Tensor Imaging
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Tracking the Mammary Architectural Features and Detecting Breast Cancer with Magnetic Resonance Diffusion Tensor Imaging

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Molecular breast imaging.

Michael O'Connor1, Deborah Rhodes, Carrie Hruska

  • 1Department of Radiology, Mayo Clinic, Rochester, MN 55905, USA. mkoconnor@mayo.edu

Expert Review of Anticancer Therapy
|August 13, 2009
PubMed
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This summary is machine-generated.

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Molecular breast imaging (MBI) offers high-resolution functional images for breast cancer detection. This nuclear medicine technique shows high sensitivity, detecting significantly more cancers than mammography in high-risk women.

Area of Science:

  • Nuclear medicine
  • Medical imaging
  • Oncology

Background:

  • Molecular breast imaging (MBI) is an advanced nuclear medicine technique.
  • It uses semiconductor gamma-cameras in a mammographic setup for high-resolution breast imaging.
  • Tc-99m sestamibi is a commonly used, approved agent for MBI.

Purpose of the Study:

  • To evaluate the efficacy of Molecular Breast Imaging (MBI) in detecting breast lesions.
  • To compare the sensitivity and specificity of MBI with mammography and MRI.
  • To explore MBI's potential as a screening tool for high-risk populations.

Main Methods:

  • MBI utilizes small semiconductor gamma-cameras in a mammographic configuration.
  • Imaging involves light compression of the breast between detectors, with images acquired in standard projections.

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Last Updated: Jun 21, 2026

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  • Tc-99m sestamibi is administered, and imaging is performed shortly post-injection.

    • Main Results:

    • MBI demonstrates high sensitivity (90%) for detecting breast lesions, including small ones (82% for <10 mm).
    • A clinical trial showed MBI detected 2-3 times more cancers than mammography in women with dense breasts and high risk.
    • MBI's sensitivity is comparable to breast MRI, and its specificity may exceed mammography's.

    Conclusions:

    • Molecular breast imaging is a sensitive tool for detecting breast cancer, especially in high-risk individuals.
    • MBI serves as a valuable adjunct to mammography, tomosynthesis, and ultrasound.
    • Its ability to provide functional information complements anatomical imaging techniques.