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Updated: Jun 21, 2026
07:57
Assessing Whole-Body Lipid-Handling Capacity in Mice
Published on: November 24, 2020
[Fasting and nonfasting lipids--secondary publication]
Anne Langsted1, Jacob J Freiberg, Børge G Nordestgaard
1Herlev Hospital, Klinisk Biokemisk Afdeling, Herlev.
Ugeskrift for Laeger
|August 15, 2009
Summary
Nonfasting lipid levels minimally change after eating and effectively predict cardiovascular events. Elevated nonfasting total cholesterol, LDL cholesterol, and triglycerides, and low HDL cholesterol indicate a significantly higher risk.
Area of Science:
- Cardiovascular Medicine
- Clinical Chemistry
- Lipid Metabolism
Context:
- Assessing the impact of normal food intake on lipid profiles.
- Evaluating the predictive value of nonfasting lipid levels for cardiovascular events.
Purpose:
- To test the hypotheses that lipid levels minimally change postprandially and that nonfasting levels predict cardiovascular events.
Summary:
- Maximum changes in fasting lipid levels after normal food intake were minimal: total cholesterol (-0.2 mmol/l), LDL cholesterol (-0.2 mmol/l), HDL cholesterol (-0.1 mmol/l), and triglycerides (+0.3 mmol/l).
- Higher tertiles of nonfasting total cholesterol, LDL cholesterol, and triglycerides, and the lowest tertile of nonfasting HDL cholesterol were associated with a 1.7- to 2.2-fold increased risk of cardiovascular events.
Impact:
- Nonfasting lipid levels are reliable predictors of cardiovascular risk, simplifying patient assessment.
- Findings support the use of nonfasting lipid measurements in routine clinical practice for cardiovascular risk stratification.
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