Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Multiple Allele Traits01:49

Multiple Allele Traits

The Concept of Multiple Allelism
Multiple Allele Traits01:49

Multiple Allele Traits

The Concept of Multiple Allelism
Blood Types02:20

Blood Types

Human blood is classified into different types based on the presence of antigens on the red blood cell's surface and antibodies in the plasma. Proper identification of blood type is essential for successful blood transfusion. The International Society of Blood Transfusion has identified 38 human blood types based on the surface antigens on the red blood cells. The most common types are ABO, Rh, and MNS blood types.
ABO blood group
ABO antigens are glycoproteins encoded by genes present on...
Alternative RNA Splicing02:18

Alternative RNA Splicing

Alternative RNA splicing is the regulated splicing of exons and introns to produce different mature mRNAs from a single pre-mRNA. Unlike in constitutive splicing where a single gene produces a single type of mRNA, alternative splicing allows an organism to produce multiple proteins from a single gene and plays an important role in protein diversity.
There are five types of alternative RNA splicing that vary in the ways the pre-mRNA segments are removed or retained in the mature mRNA. The first...
Hemoglobin01:24

Hemoglobin

Hemoglobin is a globular protein made up of four subunits. Two of these subunits are alpha chains, and the other two are beta chains. Each subunit contains a molecule of heme, which has an iron atom and can bind to oxygen. When an oxygen molecule binds to one heme group, it changes the shape of hemoglobin, making it easier for the other heme groups to bind oxygen as well.
When all four heme groups are bound to oxygen, the resulting molecule is called oxyhemoglobin. As a result, arterial blood...
The ABO Blood Group01:12

The ABO Blood Group

The ABO blood group system is a critical element of transfusion medicine, essential for determining blood compatibility in transfusions and organ transplants. It is based on specific antigens, or agglutinogens, present on the surface of red blood cells (RBCs) and corresponding antibodies, or agglutinins, in the blood plasma.
Antigens in the ABO Blood Group System
Antigens are substances that can trigger an immune response, leading to the production of antibodies. In the ABO blood group system,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Glioblastoma-derived extracellular vesicles released after radiation promote cognitive impairment through NFκB-mediated microglial activation.

bioRxiv : the preprint server for biology·2026
Same author

KRAS Inhibitor Induced Cancer Cell Death Enhances Sensitivity to Immune-Mediated Bystander Killing of Drug-Resistant Subclones.

Cancer research·2026
Same author

Discordant Clostridioides difficile testing as a predictor of inflammatory bowel disease therapy escalation.

Inflammatory bowel diseases·2026
Same author

Human DEAH-box helicase 8 regulates HSF1-mediated stress response and cancer-associated pre-mRNA splicing in tumour cells.

NAR cancer·2026
Same author

Correction to: Elevated APOBEC3B expression drives a kataegic-like mutation signature and replication stress-related therapeutic vulnerabilities in p53-defective cells.

British journal of cancer·2026
Same author

Motorboat sound in shallow waters and implications for mitigation.

The Journal of the Acoustical Society of America·2025
Same journal

For Post-stent Patients With Atherosclerotic Coronary Vascular Disease Who Are Taking an Anticoagulant, Adding Aspirin Worsens Outcomes.

American family physician·2026
Same journal

Nausea and Vomiting During Pregnancy.

American family physician·2026
Same journal

Metabolic Dysfunction-Associated Steatotic Liver Disease: Diagnosis and Management.

American family physician·2026
Same journal

Aerobic Exercise Is the Better Exercise Modality for Knee Osteoarthritis.

American family physician·2026
Same journal

Overscreening Leads to Overdiagnosis of MASLD.

American family physician·2026
Same journal

Type 2 Diabetes: Outpatient Insulin Management.

American family physician·2026
See all related articles

Related Experiment Video

Updated: Jun 21, 2026

Detection of Residual Donor Erythroid Progenitor Cells after Hematopoietic Stem Cell Transplantation for Patients with Hemoglobinopathies
11:59

Detection of Residual Donor Erythroid Progenitor Cells after Hematopoietic Stem Cell Transplantation for Patients with Hemoglobinopathies

Published on: September 6, 2017

Alpha and beta thalassemia.

Herbert L Muncie1, James Campbell

  • 1Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA. hmunci@lsuhsc.edu

American Family Physician
|August 15, 2009
PubMed
Summary
This summary is machine-generated.

Thalassemias are inherited blood disorders affecting hemoglobin synthesis. Severity ranges from asymptomatic traits to fatal conditions requiring transfusions, iron chelation, or bone marrow transplants.

Related Experiment Videos

Last Updated: Jun 21, 2026

Detection of Residual Donor Erythroid Progenitor Cells after Hematopoietic Stem Cell Transplantation for Patients with Hemoglobinopathies
11:59

Detection of Residual Donor Erythroid Progenitor Cells after Hematopoietic Stem Cell Transplantation for Patients with Hemoglobinopathies

Published on: September 6, 2017

Area of Science:

  • Hematology
  • Genetics
  • Inherited blood disorders

Background:

  • Thalassemias are inherited disorders impacting hemoglobin chain synthesis.
  • Defects in alpha or beta globin chains lead to imbalances, causing hemolysis and impaired red blood cell production.
  • Clinical presentation varies widely, from asymptomatic carriers to severe, life-threatening anemias.

Purpose of the Study:

  • To provide a comprehensive overview of thalassemia types, their pathophysiology, clinical manifestations, and management.
  • To highlight the spectrum of disease severity and associated complications.
  • To emphasize the importance of genetic counseling and diagnostic interventions.

Main Methods:

  • Literature review of inherited hematologic disorders.
  • Analysis of globin chain synthesis defects and their impact on erythropoiesis.
  • Summarization of clinical outcomes and treatment modalities for different thalassemia types.

Main Results:

  • Alpha and beta thalassemia result from reduced or absent globin chain synthesis, leading to ineffective erythropoiesis and hemolysis.
  • Severity ranges from asymptomatic thalassemia trait to severe conditions like alpha thalassemia major (hydrops fetalis) and beta thalassemia major (anemia, skeletal abnormalities).
  • Management includes transfusions, iron chelation therapy, and potentially bone marrow transplantation, with varying life expectancies based on disease severity.

Conclusions:

  • Thalassemias encompass a spectrum of inherited blood disorders with significant clinical variability.
  • Early diagnosis, genetic counseling, and tailored management are crucial for improving patient outcomes.
  • Complications like iron overload and cardiac issues necessitate long-term monitoring and treatment.