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Updated: Jun 21, 2026
10:29
A High-throughput Compatible Assay to Evaluate Drug Efficacy against Macrophage Passaged Mycobacterium tuberculosis
Published on: March 24, 2017
Fighting tuberculosis: old drugs, new formulations.
Paolo Blasi1, Aurélie Schoubben, Stefano Giovagnoli
1University of Perugia, School of Pharmacy, Department of Chemistry and Technology of Drugs, Perugia, Italy. kaolino@unipg.it
Expert Opinion on Drug Delivery
|August 15, 2009
Summary
Innovative drug delivery systems offer new ways to treat tuberculosis. This review explores micro- and nanoparticle systems to enhance antitubercular chemotherapy effectiveness.
Area of Science:
- Pharmacology
- Drug Delivery Systems
- Infectious Diseases
Background:
- Tuberculosis (TB) remains a significant global health challenge.
- Current antitubercular therapies face limitations in efficacy and patient compliance.
- Novel drug delivery strategies are crucial for overcoming these challenges.
Purpose of the Study:
- To provide a comprehensive overview of advanced drug delivery systems for antitubercular agents.
- To critically evaluate micrometric and nanometric particulate systems for improved tuberculosis chemotherapy.
- To highlight the state-of-the-art in innovative antitubercular drug delivery.
Main Methods:
- Literature review of recent advancements in drug delivery for tuberculosis.
- Analysis of micrometric and nanometric particulate systems.
- Evaluation of strategies to enhance antitubercular chemotherapy.
Main Results:
- Various micro- and nanoparticle-based drug delivery systems have been investigated for antitubercular drugs.
- These systems show potential for improved drug targeting, reduced toxicity, and enhanced therapeutic outcomes.
- The review critically assesses the design and performance of these systems.
Conclusions:
- Innovative drug delivery strategies, particularly particulate systems, hold significant promise for advancing tuberculosis treatment.
- Further research and development are needed to translate these findings into clinical practice.
- Optimized delivery systems can potentially overcome limitations of current antitubercular therapies.
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