Related Experiment Video
Updated: Jun 21, 2026
05:26
Examination of Oral Candida Infection in Primary Sjögren's Syndrome Patients
Published on: March 1, 2024
Renal involvement in primary Sjögren's syndrome: a clinicopathologic study
Saugar Maripuri1, Joseph P Grande, Thomas G Osborn
1Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA.
Clinical Journal of the American Society of Nephrology : CJASN
|August 15, 2009
Summary
Kidney biopsies in primary Sjögren's syndrome (pSS) reveal tubulointerstitial nephritis as the main finding. Early treatment with immunosuppressants helps preserve kidney function in most affected patients.
Area of Science:
- Nephrology
- Rheumatology
- Pathology
Background:
- Primary Sjögren's syndrome (pSS) can affect the kidneys, leading to renal impairment.
- Kidney biopsy (KB) is crucial for diagnosing renal pathology in pSS patients with kidney dysfunction.
Purpose of the Study:
- To report renal pathology and clinical outcomes in patients with pSS who underwent KB due to renal impairment.
- To evaluate the impact of treatment on renal function in these patients.
Main Methods:
- A retrospective review of 24 patients with pSS who underwent KB over 40 years.
- Cases were analyzed by renal pathologists, nephrologists, and rheumatologists, noting presentation, lab findings, pathology, treatment, and response.
Main Results:
- Tubulointerstitial nephritis (TIN) was the primary lesion in 71% of patients, with chronic TIN being most common (65%).
- Eighty-three percent of patients were initially treated with corticosteroids; 14 of 16 followed for over a year maintained or improved renal function.
- No patients presenting with stage IV chronic kidney disease progressed to stage V with treatment.
Conclusions:
- Chronic TIN is the predominant KB finding in renal involvement from pSS, alongside diverse glomerular lesions.
- KB is recommended for evaluating kidney dysfunction in pSS and may serve as a classification criterion.
- Treatment with glucocorticoids or immunosuppressants appears to slow renal disease progression.
Related Concept Videos
01:26Nephrotic Syndrome II : Assessment and Medical Management
IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document any history...
01:24Nephrotic Syndrome I : Introduction
Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of fluid...
01:22Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies
The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
01:15Secondary Lymphoid Organs
Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
01:22Myasthenia Gravis ll: Pathophysiology
The disease process of myasthenia gravis begins at the neuromuscular junction, where antibodies attack key proteins needed for muscle activation. This immune reaction weakens signal transmission, leading to the characteristic muscle fatigue and weakness that define the condition.Immune-Mediated DamageIn most individuals, antibodies target acetylcholine receptors (AChRs) on the postsynaptic membrane of muscle cells. By blocking acetylcholine binding, these antibodies prevent the nerve signal...
01:16Primary Lymphoid Organs
Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...