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Leishmaniasis

Leishmaniasis

Leishmaniasis is a protozoal disease caused by species of the genus Leishmania and transmitted through the bite of infected female sandflies. The parasite exists in two principal morphological forms during its life cycle. A sandfly acquires intracellular amastigotes from an infected reservoir host, such as a dog. Within the sandfly, these forms differentiate into motile, flagellated promastigotes. During a subsequent blood meal, promastigotes are injected into the human host, where they...

Antiprotozoal Agents

Antiprotozoal Agents

Leishmaniasis is a widespread parasitic disease caused by several Leishmania species. It affects millions of people each year and remains a major public health problem in endemic regions. First-line treatment relies on pentavalent antimonials, including meglumine antimoniate and sodium stibogluconate. Even so, how these drugs work has not been fully clear, especially their interaction with parasite-specific biochemical pathways. One key target is trypanothione reductase (TR), an enzyme that...

American Trypanosomiasis

American Trypanosomiasis

Chagas disease, or American trypanosomiasis, is a vector-borne parasitic infection caused by Trypanosoma cruzi, a flagellated protozoan (kinetoplastid) of the family Trypanosomatidae. The disease is endemic in Latin America, although cases are increasingly reported worldwide due to human migration. Transmission most commonly occurs when feces of infected triatomine bugs contaminate bite wounds or mucosal surfaces; additional routes include congenital, transfusional, transplant-related, and oral...

Skin Diseases and Disorders

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...

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Related Experiment Video

Updated: Jun 21, 2026

Cutaneous Leishmaniasis in the Dorsal Skin of Hamsters: a Useful Model for the Screening of Antileishmanial Drugs

Cutaneous Leishmaniasis in the Dorsal Skin of Hamsters: a Useful Model for the Screening of Antileishmanial Drugs

Published on: April 21, 2012

[Cutaneous leishmaniasis. A case report.].

S Davidsson, J H Olafsson, S Hardarson

|August 15, 2009

Summary

This summary is machine-generated.

A traveler contracted cutaneous leishmaniasis in South America. Treatment with sodium stibogluconate was successful, highlighting the need for vigilance regarding tropical diseases in Iceland.

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Cutaneous Leishmaniasis in the Dorsal Skin of Hamsters: a Useful Model for the Screening of Antileishmanial Drugs

Cutaneous Leishmaniasis in the Dorsal Skin of Hamsters: a Useful Model for the Screening of Antileishmanial Drugs

Published on: April 21, 2012

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Published on: February 20, 2020

Area of Science:

Tropical medicine
Infectious diseases
Parasitology

Context:

Cutaneous leishmaniasis is endemic in South America and the Middle East.
Increased international travel raises the risk of importing tropical diseases.
A case study of a young Icelander highlights disease transmission risks.

Purpose:

To report a case of cutaneous leishmaniasis in an Icelander returning from South America.
To discuss the successful treatment of cutaneous leishmaniasis.
To emphasize the potential for emerging infectious diseases in non-endemic regions.

Summary:

A 20-year-old Icelander was diagnosed with cutaneous leishmaniasis after traveling in South America.
The patient received successful treatment with sodium stibogluconate, an antimonial drug.
This case underscores the importance of considering tropical infections in travelers.

Impact:

Suggests a potential increase in imported tropical infectious diseases in Iceland.
Highlights the efficacy of sodium stibogluconate for cutaneous leishmaniasis.
Emphasizes the need for increased awareness and diagnostic preparedness for tropical diseases in Iceland.