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Updated: Jun 20, 2026

Transfer of Manipulated Tumor-associated Neutrophils into Tumor-Bearing Mice to Study their Angiogenic Potential In Vivo
08:19

Transfer of Manipulated Tumor-associated Neutrophils into Tumor-Bearing Mice to Study their Angiogenic Potential In Vivo

Published on: July 20, 2019

Type I interferon drives tumor necrosis factor-induced lethal shock

Liesbeth Huys1, Filip Van Hauwermeiren, Lien Dejager

  • 1Department for Molecular Biomedical Research, VIB, Ghent B9052, Belgium.

The Journal of Experimental Medicine
|August 19, 2009
PubMed
Summary

Type I interferons (IFNs) are crucial mediators of lethal responses to tumor necrosis factor (TNF). Blocking type I IFN signaling protects against TNF-induced inflammatory shock, suggesting safer therapeutic applications for TNF.

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