Related Experiment Video
Updated: Jun 20, 2026
09:25
Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma
Published on: October 14, 2016
Childhood cutaneous leiomyosarcoma
Géraldine Blaise1, Arjen F Nikkels, Pascale Quatresooz
1Department of Dermatopathology, University Hospital of Liège, Liège, Belgium.
Pediatric Dermatology
|August 20, 2009
Summary
Cutaneous leiomyosarcoma, a rare childhood soft tissue cancer, is aggressive and can spread. Surgical removal with wide margins is the primary treatment, with no role for radiation or chemotherapy.
Area of Science:
- Oncology
- Dermatology
- Surgical Pathology
Background:
- Cutaneous leiomyosarcoma (CLS) is a rare soft tissue neoplasm.
- CLS presents with aggressive local behavior and metastatic potential.
- Pediatric CLS diagnosis is clinically and histologically challenging.
Observation:
- CLS exhibits aggressive local behavior.
- CLS has a potential for distant metastases.
- CLS is rare in childhood.
Findings:
- Wide surgical excision with deep and lateral margins is the treatment of choice for CLS.
- Radiotherapy and chemotherapy are contraindicated for CLS.
- Long-term follow-up is essential due to frequent recurrences.
Implications:
- Early and accurate diagnosis of pediatric CLS is crucial.
- Surgical management is paramount for effective CLS treatment.
- Ongoing surveillance is necessary to monitor for CLS recurrence.
Related Concept Videos
01:30Skin Cancer
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
01:03Rous Sarcoma Virus (RSV) and Cancer
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
01:23Skin Diseases and Disorders
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
01:30Leishmaniasis
Leishmaniasis is a protozoal disease caused by species of the genus Leishmania and transmitted through the bite of infected female sandflies. The parasite exists in two principal morphological forms during its life cycle. A sandfly acquires intracellular amastigotes from an infected reservoir host, such as a dog. Within the sandfly, these forms differentiate into motile, flagellated promastigotes. During a subsequent blood meal, promastigotes are injected into the human host, where they...
01:20The Retinoblastoma Gene
Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...