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IL-17 inhibits human Th1 differentiation through IL-12R beta 2 downregulation

Myew-Ling Toh1, Masanori Kawashima, Saloua Zrioual

  • 1Department of Immunology, University of Lyon, Edouard Herriot Hospital, Lyon, France.

Cytokine
|August 21, 2009
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T Cell Types and Functions01:24

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When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...