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Updated: Jun 20, 2026

Mouse Naïve CD4+ T Cell Isolation and In vitro Differentiation into T Cell Subsets
Published on: April 16, 2015
From IL-10 to IL-12: how pathogens and their products stimulate APCs to induce T(H)1 development
Anne O'Garra1, Kenneth M Murphy
1Division of Immunoregulation, The Medical Research Council National Institute for Medical Research, London, UK. aogarra@nimr.mrc.ac.uk
Abstract:
The authors recount their discovery of how pathogen-induced interleukin 12 production leads to T(H)1 T cell polarization. Simultaneously they discovered the suppressive cytokine interleukin 10 inhibits antigen-presenting cells, thus regulating development of T(H)1 cells.
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