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Dynamic susceptibility contrast perfusion MR imaging in distinguishing malignant from benign head and neck tumors: a
Ahmed Abdel Khalek Abdel Razek1, Lamiaa Galal Elsorogy, Nermin Yehia Soliman
1Diagnostic Radiology Department, Mansoura Faculty of Medicine, Mansoura, Egypt. arazek@mans.eun.eg
Purpose:
To preliminarily investigate the utility of dynamic susceptibility contrast perfusion MR imaging in distinguishing malignant from benign head and neck tumors.
Material And Methods:
Seventy eight patients with head and neck masses underwent single shot dynamic susceptibility contrast T2*-weighted perfusion weighted MR imaging after bolus infusion of gadolinium-DTPA was administrated. The signal intensity time curve of the lesion was created. Dynamic susceptibility contrast percentage (DSC%) was calculated and correlated with pathological findings.
Results:
The mean DSC% of malignant tumor (n=40) was 39.3±9.6% and of benign lesions (n=38) was 24.3±10.3%. There was a statistically significant difference of the DSC% between benign and malignant tumors (P=0.001) and within benign tumors (P=0.001). When DSC% of 30.7% was used as a threshold for differentiating malignant from benign tumors, the best results were obtained: accuracy of 84.6%, sensitivity of 80% and specificity of 89.2%.
Conclusion:
Dynamic susceptibility contrast perfusion weighted MR imaging is a non-invasive imaging technique that can play a role in differentiation between malignant and benign head and neck tumors.
Insights
Dynamic susceptibility contrast perfusion MRI can help differentiate malignant from benign head and neck tumors. This non-invasive technique showed significant differences in perfusion values, aiding in diagnosis.
Area of Science:
- Radiology
- Oncology
- Medical Imaging
Background:
- Head and neck tumors present a diagnostic challenge.
- Accurate differentiation between malignant and benign lesions is crucial for treatment planning.
Purpose of the Study:
- To evaluate the effectiveness of dynamic susceptibility contrast perfusion MR imaging (DSC Perfusion MRI) in distinguishing malignant from benign head and neck tumors.
- To assess the diagnostic performance of DSC Perfusion MRI parameters.
Main Methods:
- Seventy-eight patients with head and neck masses underwent DSC Perfusion MRI.
- Gadolinium-DTPA was administered as a bolus infusion.
- Signal intensity-time curves were analyzed, and dynamic susceptibility contrast percentage (DSC%) was calculated.
Main Results:
- Mean DSC% was significantly higher in malignant tumors (39.3±9.6%) compared to benign lesions (24.3±10.3%).
- A DSC% threshold of 30.7% achieved 84.6% accuracy, 80% sensitivity, and 89.2% specificity in differentiating tumor types.
- Statistical significance was observed in DSC% differences (P=0.001).
Conclusions:
- DSC Perfusion MRI is a valuable non-invasive tool for differentiating malignant and benign head and neck tumors.
- The technique offers a promising approach to improve diagnostic accuracy in head and neck oncology.
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