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Related Concept Videos

Obsessive-Compulsive Disorder01:28

Obsessive-Compulsive Disorder

Obsessive-compulsive disorder (OCD) is a mental health condition characterized by recurrent obsessions, compulsions, or both, which consume significant time and interfere with daily functioning. Obsessions involve persistent, intrusive, and unwanted thoughts, images, or urges that evoke anxiety. Common examples include irrational fears of contamination or harm. Compulsions are repetitive behaviors or mental acts performed to reduce the anxiety caused by obsessions. For instance, individuals...
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Depressive disorders are a group of mental health conditions characterized by pervasive feelings of sadness, diminished pleasure in life, and a significant impact on daily functioning. These conditions are most prevalent in individuals during their 30s and affect women at twice the rate of men. Contrary to popular belief, younger individuals are generally more susceptible to these disorders than older adults. Two key types of depressive disorders include Major Depressive Disorder (MDD) and...
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Depression: Overview

Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...
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Related Experiment Video

Updated: Jun 20, 2026

Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging
09:14

Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging

Published on: March 14, 2025

Comorbidity in obsessive-compulsive disorder: focus on depression.

A Milanfranchi, D Marazziti, C Pfanner

    European Psychiatry : the Journal of the Association of European Psychiatrists
    |August 25, 2009
    PubMed
    Summary

    Major depressive disorder (MDD) is the most common comorbidity with obsessive-compulsive disorder (OCD), affecting nearly 20% of patients. The presence of MDD was found to delay the effectiveness of clomipramine treatment for OCD.

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    Area of Science:

    • Psychiatry
    • Clinical Psychology

    Background:

    • Obsessive-compulsive disorder (OCD) frequently co-occurs with other psychiatric conditions.
    • Understanding these comorbidities is crucial for effective treatment planning.

    Purpose of the Study:

    • To investigate the comorbidity patterns of OCD in outpatients.
    • To examine the impact of major depressive disorder (MDD) on clomipramine treatment outcomes for OCD.

    Main Methods:

    • Cross-sectional study of 154 outpatients diagnosed with OCD.
    • Subgroup analysis of 52 patients treated with clomipramine to assess the influence of comorbid MDD.

    Main Results:

    • Major depressive disorder (MDD) was the most frequent comorbidity, present in approximately 20% of OCD patients.
    • Generalized anxiety disorder and panic disorder were also common comorbidities.
    • The co-occurrence of MDD was associated with a delayed therapeutic effect of clomipramine.

    Conclusions:

    • MDD is a highly prevalent comorbidity in OCD patients.
    • Clinicians should consider the impact of comorbid depression when initiating clomipramine treatment for OCD.
    • Further research into managing complex comorbidity profiles in OCD is warranted.