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Transient Middle Cerebral Artery Occlusion Model of Neonatal Stroke in P10 Rats
Published on: April 21, 2017
Neonatal cerebral sinovenous thrombosis
Luca A Ramenghi1, Paul Govaert, Monica Fumagalli
1Neonatal Intensive Care Unit-Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, IRCCS, University of Milan, Via Commenda 12, 20122 Milan, Italy. luca.ramenghi@mangiagalli.it
Seminars in Fetal & Neonatal Medicine
|August 25, 2009
Summary
Cerebral sinovenous thrombosis (CSVT) is rare in children, especially neonates, presenting unspecifically. Diagnosis is challenging due to varied symptoms and reliance on expert consensus for treatment.
Area of Science:
- Pediatric Neurology
- Vascular Neurology
- Neonatology
Background:
- Cerebral sinovenous thrombosis (CSVT) is an uncommon condition in pediatric patients, predominantly affecting neonates.
- Clinical presentation is non-specific, with early onset (within 48 hours of birth) often linked to comorbidities, and later onset associated with neurological signs like seizures and lethargy.
Purpose of the Study:
- To highlight the diagnostic challenges of pediatric cerebral sinovenous thrombosis (CSVT).
- To discuss the complex pathogenesis involving inherited and acquired thrombophilic factors.
- To review current treatment approaches based on expert consensus.
Main Methods:
- Review of clinical presentations and diagnostic difficulties of CSVT in neonates and children.
- Discussion of the etiological factors contributing to CSVT.
- Analysis of current therapeutic strategies.
Main Results:
- CSVT presentation varies significantly between early and late onset, complicating early diagnosis.
- Neuroradiological diagnosis was particularly challenging before the advent of MRI.
- The pathogenesis is multifactorial, involving both genetic and acquired thrombophilia.
Conclusions:
- Pediatric cerebral sinovenous thrombosis (CSVT) presents diagnostic challenges due to unspecific symptoms.
- Understanding the complex pathogenesis is crucial for managing this condition.
- Current treatments rely on expert consensus rather than randomized trials.
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