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Related Concept Videos

Diabetic Foot Ulcer01:31

Diabetic Foot Ulcer

Definition A diabetic foot ulcer (DFU) is a chronic, non-healing wound that develops in individuals with diabetes. It typically occurs on pressure-bearing areas such as the heel, metatarsal heads, or hallux, and carries a high risk of infection and amputation.Pathophysiology • The development of DFUs can be explained by four interconnected mechanisms: neuropathy, ischemia, infection, and impaired wound healing. • Neuropathy is the most common factor. Sensory neuropathy reduces pain perception,...
Diabetic Retinopathy01:27

Diabetic Retinopathy

DefinitionDiabetic retinopathy is a microvascular complication of diabetes affecting the retinal blood vessels.Risk FactorsDiabetic retinopathy is present in almost all individuals with type 1 diabetes and more than 60% of those with type 2 diabetes after two decades of disease.The risk increases with poor glycemic control, hypertension, dyslipidemia, smoking, pregnancy, and puberty.Although cataracts and glaucoma are also more frequent in people with diabetes, retinopathy remains the leading...
Complications of Diabetes Mellitus01:22

Complications of Diabetes Mellitus

Diabetes mellitus is a chronic metabolic disorder characterized by persistent hyperglycemia due to insulin deficiency, resistance, or both. Prolonged hyperglycemia disrupts metabolic homeostasis and leads to acute and chronic complications.Acute ComplicationsAcute complications result from sudden metabolic imbalance.Diabetic ketoacidosis (DKA) mainly appears in type 1 diabetes but may also develop in type 2 diabetes, particularly under extreme stress. It arises from severe insulin deficiency,...
Peripheral Artery Disease V: Postoperative Nursing Management01:23

Peripheral Artery Disease V: Postoperative Nursing Management

During the postoperative period, it is crucial to focus on maintaining circulation, identifying and managing potential complications, and planning for discharge.Nursing AssessmentVital signs monitoring: Regularly monitor vital signs, including blood pressure, heart rate, respiratory rate, and temperature, to detect early signs of complications such as bleeding and infection.Circulation assessment: Monitor pulses, perform Doppler assessments, and check capillary refill, color, temperature, and...
Type II Diabetes II: Pathophysiology01:24

Type II Diabetes II: Pathophysiology

PathophysiologyType 2 diabetes mellitus (T2DM ) is a chronic metabolic disorder characterized by insulin resistance and progressive pancreatic β-cell dysfunction, leading to impaired glucose homeostasis. It results from interactions among genetic predisposition, environmental factors, and metabolic stressors, such as overnutrition and a sedentary lifestyle.Insulin Resistance and Glucose DysregulationEarly T2DM involves insulin resistance in skeletal muscle, adipose tissue, and the liver.
Type I Diabetes II: Pathophysiology01:26

Type I Diabetes II: Pathophysiology

Type 1 diabetes mellitus arises from an immune-mediated destruction of pancreatic β-cells, resulting in an absolute deficiency of insulin. This process develops in genetically susceptible individuals when autoimmunity, environmental exposures, and immunologic dysregulation converge to trigger a targeted attack on the insulin-producing cells of the pancreas. The β-cells are located within the islets of Langerhans and are essential for regulating blood glucose by facilitating cellular uptake of...

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Related Experiment Video

Updated: Jun 20, 2026

Predicting Amputation using Local Circulating Mononuclear Progenitor Cells in Angioplasty-treated Patients with Critical Limb Ischemia
07:25

Predicting Amputation using Local Circulating Mononuclear Progenitor Cells in Angioplasty-treated Patients with Critical Limb Ischemia

Published on: September 22, 2020

Decreasing amputation rates in patients with diabetes-a population-based study.

C J Schofield1, N Yu, A S Jain

  • 1Ninewells Hospital and Medical School, Dundee, UK. cschofield@nhs.net

Diabetic Medicine : a Journal of the British Diabetic Association
|August 28, 2009
PubMed
Summary
This summary is machine-generated.

The rate of major lower extremity amputations in patients with diabetes significantly decreased over a 7-year period. This study tracked amputation trends in diabetic patients from 2000 to 2006.

Related Experiment Videos

Last Updated: Jun 20, 2026

Predicting Amputation using Local Circulating Mononuclear Progenitor Cells in Angioplasty-treated Patients with Critical Limb Ischemia
07:25

Predicting Amputation using Local Circulating Mononuclear Progenitor Cells in Angioplasty-treated Patients with Critical Limb Ischemia

Published on: September 22, 2020

Area of Science:

  • Podiatry
  • Diabetology
  • Public Health

Background:

  • Lower extremity amputations are a serious complication of diabetes.
  • Monitoring amputation rates is crucial for assessing the effectiveness of preventative strategies.

Purpose of the Study:

  • To evaluate the trend in lower extremity amputation incidence among diabetic patients over a 7-year period.
  • To determine if there has been a significant change in amputation rates during this timeframe.

Main Methods:

  • Retrospective analysis of lower extremity amputations in Tayside, Scotland (2000-2006).
  • Data linkage between amputation cases and a diabetes patient database.
  • Statistical analysis to assess trends in amputation incidence, adjusted for age, sex, and diabetes duration.

Main Results:

  • A significant decline in the incidence of major lower extremity amputations was observed in diabetic patients.
  • The incidence of major amputations decreased from 5.1 to 2.9 per 1000 diabetic patients (P < 0.05).
  • Adjusted analyses confirmed a clear linear decreasing trend in both major and total amputations over the study period.

Conclusions:

  • A substantial reduction in major lower extremity amputations occurred in the diabetic population studied.
  • The findings suggest successful interventions or improved management contributing to decreased amputation rates.
  • Continued monitoring and research are warranted to sustain and further improve outcomes for diabetic foot complications.