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Related Concept Videos

Vitamins01:30

Vitamins

Vitamins, derived from the Latin word for life, are essential organic substances required in small quantities for optimal growth and overall well-being. Unlike other organic nutrients, vitamins don't act as sources of energy or building materials but rather facilitate these nutrients' utilization by the body. Vitamins are predominantly coenzymes, assisting enzymes in specific chemical actions, like the oxidation of glucose for energy involving B vitamins. Most vitamins are not produced in our...
Gastritis-II: Pathophysiology01:17

Gastritis-II: Pathophysiology

Gastritis is marked by disruption of the mucosal barrier that usually protects the stomach tissue from digestive juices and manifests in acute and chronic forms.
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
Gastritis II: Pathophysiology01:26

Gastritis II: Pathophysiology

The pathophysiology of gastritis begins with the colonization of the stomach lining by Helicobacter pylori (H. pylori). This bacterium spreads mainly via the oral-oral route through saliva or shared utensils, and can also be transmitted in overcrowded or unhygienic environments through contaminated water, despite its brief survival outside the body.ColonizationOnce ingested, H. pylori enters the stomach and begins colonization by navigating through the mucus layer lining the stomach wall. It...
Enteral Nutrition II: Nasointestinal and Gastrostomy Feeding01:15

Enteral Nutrition II: Nasointestinal and Gastrostomy Feeding

Enteral nutrition encompasses various methods of delivering nutrition directly to the gastrointestinal (GI) tract, bypassing traditional oral intake. It is particularly beneficial for patients who cannot eat by mouth but have a functioning digestive system. Key methods include nasointestinal feeding, gastrostomy, and jejunostomy, each suited to different clinical scenarios based on the patient's needs and condition.
Nasointestinal Feeding
Nasointestinal feeding involves placing a tube through...
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the colonic...
Gastroesophageal Reflux Disease I: Meaning and Pathophysiology01:29

Gastroesophageal Reflux Disease I: Meaning and Pathophysiology

Gastroesophageal Reflux Disease (GERD) involves the recurrent backflow of the stomach or duodenal contents into the esophagus, leading to troublesome symptoms and potential esophageal mucosal damage. Although GERD is often referred to as a disease, it is more accurately described as a syndrome, as it encompasses a range of symptoms and complications rather than a singular pathological entity, impacting a large number of individuals as the most prevalent upper gastrointestinal problem. Roughly...

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Related Experiment Videos

Correlation between neurological dysfunction with vitamin E deficiency and gastrectomy.

Naohisa Ueda1, Yume Suzuki, Yasushi Rino

  • 1Department of Neurology, Yokohama City University School of Medicine, Yokohama, Kanagawa, Japan. uedan@ck9.so-net.ne.jp

Journal of the Neurological Sciences
|August 28, 2009
PubMed
Summary

Gastrectomy patients may experience vitamin E deficiency and neurological issues long-term. Supplementing with oral vitamin E (300mg+) can restore vitamin E levels and improve neurological symptoms.

Related Experiment Videos

Area of Science:

  • Gastroenterology
  • Neurology
  • Nutritional Science

Background:

  • Vitamin E malabsorption is a known complication following gastrectomy.
  • Long-term neurological dysfunction due to vitamin E deficiency post-gastrectomy requires further investigation.

Purpose of the Study:

  • To investigate the incidence and characteristics of neurological dysfunction associated with low serum vitamin E levels in a larger cohort of gastrectomy patients.
  • To evaluate the efficacy of oral vitamin E supplementation in correcting vitamin E deficiency and improving neurological symptoms.

Main Methods:

  • A cohort of 96 gastrectomy patients was assessed for gastrectomy type, reconstruction method, serum vitamin E levels, and neurological status.
  • Serum vitamin E levels and neurological symptoms were monitored over time post-gastrectomy.
  • Patients with low vitamin E levels received oral vitamin E supplementation, and outcomes were evaluated.

Main Results:

  • Twenty out of 96 patients exhibited low serum vitamin E levels, with 10 experiencing neurological symptoms like peripheral neuropathy or ataxia.
  • Vitamin E levels decreased over time, particularly around 50 months post-gastrectomy, with a stronger association in total gastrectomy patients.
  • Oral vitamin E supplementation (≥300 mg/day) normalized vitamin E levels in 90% of treated patients and improved neurological abnormalities in 80%.

Conclusions:

  • Gastrectomy poses a long-term risk for vitamin E deficiency and subsequent neurological disturbances.
  • Oral vitamin E supplementation is an effective strategy for managing vitamin E deficiency and improving neurological outcomes in post-gastrectomy patients.