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Updated: Jun 20, 2026

Coherent anti-Stokes Raman Scattering (CARS) Microscopy Visualizes Pharmaceutical Tablets During Dissolution
Published on: July 4, 2014
Raman microscopic evaluation of technology dependent structural differences in tablets containing imipramine model
Balázs Vajna1, István Farkas, András Szabó
1Department of Organic Chemistry and Technology, Budapest University of Technology and Economics, Budapest, Hungary. balazs.vajna@gmail.com
Raman imaging effectively detects how manufacturing methods impact tablet properties like compound distribution and strength. This chemical imaging technique also offers a way to estimate component mass fractions in pharmaceutical tablets.
Area of Science:
- Pharmaceutical Technology
- Analytical Chemistry
- Materials Science
Background:
- Tablet manufacturing involves complex processes influencing final product properties.
- Characterizing compound distribution and physical properties is crucial for tablet quality control.
- Raman imaging offers a non-destructive method for chemical analysis of solid dosage forms.
Purpose of the Study:
- To investigate the influence of different manufacturing technologies on tablet properties using Raman imaging.
- To correlate observed chemical and physical variations with specific manufacturing methods.
- To evaluate the capability of Raman imaging for quantitative component analysis.
Main Methods:
- Utilized Raman imaging to analyze tablets produced with varying manufacturing technologies.
- Employed direct classical least squares (DCLS) modeling for chemical map analysis.
- Assessed visual appearance and statistical properties of component scores.
- Correlated chemical imaging data with tablet mechanical properties.
Main Results:
- Raman imaging successfully detected differences in active pharmaceutical ingredient (API) and excipient distribution.
- Variations in compound distribution were closely linked to the granulation method used.
- Chemical imaging data correlated with the mechanical strength of the tablets.
- The method provided a cautious estimation of component mass fractions.
Conclusions:
- Raman imaging is a valuable tool for characterizing the impact of manufacturing processes on tablet homogeneity and properties.
- Chemical imaging can reveal relationships between manufacturing techniques, physical tablet characteristics, and API distribution.
- The developed approach shows potential for both qualitative and quantitative analysis of pharmaceutical tablet composition.
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