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Circadian Rhythms and Gene Regulation

Circadian Rhythms and Gene Regulation

The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent years,...

Circadian Rhythms and Gene Regulation

Circadian Rhythms and Gene Regulation

The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent years,...

Genomics

Genomics

Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...

Chronopharmacokinetics: Time-Dependent Pharmacokinetics

Chronopharmacokinetics: Time-Dependent Pharmacokinetics

Chronopharmacokinetics studies the temporal change in drug absorption and elimination. These changes can be cyclical or non-cyclical. Cyclical changes occur over a regular interval, while non-cyclical changes occur over a longer, irregular period.
Time-dependent pharmacokinetics refers to non-cyclical changes in drug rate processes over a period of time. It can lead to nonlinear pharmacokinetics, where the relationship between drug concentration and time is not proportional. Non-cyclical...

Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response

Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response

Circadian rhythms are cyclic changes that are crucial in plasma drug concentrations. Various standard circadian parameters, including core body temperature, heart rate, and other cardiovascular factors, directly impact disease states and the therapeutic response to drug therapy.
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...

Biological Clocks and Seasonal Responses

Biological Clocks and Seasonal Responses

The circadian—or biological—clock is an intrinsic, timekeeping, molecular mechanism that allows plants to coordinate physiological activities over 24-hour cycles called circadian rhythms. Photoperiodism is a collective term for the biological responses of plants to variations in the relative lengths of dark and light periods. The period of light-exposure is called the photoperiod.

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Related Experiment Video

Updated: Jun 20, 2026

Studying Age-dependent Genomic Instability using the S. cerevisiae Chronological Lifespan Model

Studying Age-dependent Genomic Instability using the S. cerevisiae Chronological Lifespan Model

Published on: September 29, 2011

CHRONOMICS AND GENETICS.

F Halberg¹, G Cornélissen, G Katinas

¹University of Minnesota, Minneapolis, Minnesota, USA.

|August 28, 2009

Summary

This summary is machine-generated.

Chronobiology

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Studying Age-dependent Genomic Instability using the S. cerevisiae Chronological Lifespan Model

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Area of Science:

Chronobiology
Biosphere research
Cosmobiology

Background:

Time structures, or chronomes, are fundamental to Earth's biosphere.
Understanding these cycles is crucial for transdisciplinary research.
Chronobiology offers tools to map these temporal patterns.

Purpose of the Study:

To introduce chronomics as the mapping of time structures.
To present methods for analyzing environmental and biological cycles.
To illustrate the importance of mapping rhythm characteristics across timescales.

Main Methods:

Utilizing analytical statistical documentation with superposed epochs and cycles.
Employing 'remove-and-replace' approaches with environmental factors.
Mapping rhythms across approximately 10, 20, and 50-year scales within the BIOCOS project.

Main Results:

Demonstrated the indispensability of mapping rhythm characteristics in broader chronomes.
Presented findings from cooperative cartography of multi-decadal rhythms.
Highlighted the transdisciplinary nature and broad importance of these cyclic findings.

Conclusions:

Chronomics provides a framework for understanding Earth's temporal organization.
The study of biosphere and cosmic rhythms is essential for scientific advancement.
Further research into biological rhythms may reveal influences sought by earlier scientists.