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Detecting the Lyme Disease Spirochete, Borrelia Burgdorferi, in Ticks Using Nested PCR
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NB-LRRs work a "bait and switch" on pathogens.

Sarah M Collier1, Peter Moffett

  • 1Boyce Thompson Institute for Plant Research, Ithaca, NY 14853, USA.

Trends in Plant Science
|September 2, 2009
PubMed
Summary
This summary is machine-generated.

Nucleotide binding leucine-rich repeat (NB-LRR) proteins are key plant disease resistance components. A new "bait and switch" model explains their function through a two-step recognition process involving cellular cofactors and LRR domains.

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Area of Science:

  • Plant pathology
  • Molecular biology
  • Genetics

Background:

  • Plant genomes contain numerous nucleotide binding leucine-rich repeat (NB-LRR) proteins, crucial for disease resistance.
  • While the C-terminal LRR domain's role in pathogen recognition is established, N-terminal functions are increasingly recognized.

Purpose of the Study:

  • To propose a unifying "bait and switch" model for NB-LRR protein function.
  • To integrate diverse experimental findings into a cohesive framework for NB-LRR-mediated immunity.

Main Methods:

  • Theoretical modeling based on existing literature and experimental data.
  • Comparative analysis of NB-LRR protein structures and functions.

Main Results:

  • The proposed "bait and switch" model outlines a two-step pathogen recognition mechanism.
  • This model incorporates interactions with cellular cofactors ('bait') and the LRR domain.

Conclusions:

  • The "bait and switch" model provides a comprehensive framework for understanding NB-LRR protein activation.
  • This model highlights the synergistic roles of N-terminal interactions and LRR domains in plant disease resistance.