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Type A aortic dissection manifesting as acute myocardial infarction: still a lesson to learn
Jing-Ling Luo1, Cho-Kai Wu, Yen-Hung Lin
1Division of Cardiology, Dept. of Internal Medicine, Keelung Hospital, Dept. of Health, Executive Yuan, Keelung, Taiwan.
Insights
Type A aortic dissection mimicking acute myocardial infarction (AMI) is rare and dangerous. Early transthoracic echocardiography (TTE) and D-dimer tests can help diagnose this condition, improving patient outcomes.
Area of Science:
- Cardiology
- Vascular Surgery
Background:
- Type A aortic dissection presenting as acute myocardial infarction (AMI) is a rare but life-threatening condition.
- Delayed or incorrect management can lead to catastrophic outcomes.
Purpose of the Study:
- To investigate the incidence, outcomes, and diagnostic challenges of Type A aortic dissection presenting as AMI.
- To propose a diagnostic paradigm for this specific presentation.
Main Methods:
- Retrospective review of 531 patients with acute aortic dissection from 1995 to 2006.
- Analysis of 239 patients diagnosed with Stanford Type A aortic dissection.
- Focus on the 11 patients (5%) who initially presented with AMI.
Main Results:
- Stanford Type A aortic dissection had a 17% mortality rate.
- Patients presenting with AMI had a significantly higher mortality rate of 36%.
- Diagnostic pitfalls included misinterpretation of echocardiography findings and delayed suspicion of aortic dissection.
Conclusions:
- Type A aortic dissection mimicking AMI is a critical condition requiring prompt recognition.
- Transthoracic echocardiography (TTE) and D-dimer levels are crucial in identifying this hidden diagnosis.
- Implementing a focused diagnostic approach can improve patient survival.
Objective:
Type A aortic dissection manifesting as acute myocardial infarction (AMI) is relatively rare but could be catastrophic if the management is not appropriate. This study investigated the incidence, outcome and potential diagnostic pitfalls of patients with such manifestations, and proposes a useful diagnostic paradigm.
Methods And Results:
From 1 January 1995 to 31 July 2006, 531 patients admitted to our hospital with the initial or later diagnosis of acute aortic dissection were reviewed. Two hundred and thirty-nine patients were diagnosed as Stanford type A aortic dissection with a mortality rate of 17% (41/239). Eleven (5%) of the 239 patients had initial presentation of AMI (chest pain and elevation of cardiac enzymes, with or without ST-segment elevation) and a high mortality rate of 36% (4/11). All six patients with ST-segment elevation underwent coronary angiography without awareness of type A aortic dissection; three patients were detected to have eccentric aortic regurgitation by transthoracic echocardiography (TTE) before angiography but type A aortic dissection was neglected at that time. Three of the five patients without ST-segment elevation also had eccentric aortic regurgitation by TTE before the confirmative diagnosis was made; prompt suspicion of type A aortic dissection was assisted with an elevation of D-dimer value in one of these three patients. The presence of eccentric aortic regurgitation by TTE, and the increased D-dimer value provided hints of the coexistence of AMI and type A aortic dissection.
Conclusions:
Type A aortic dissection manifesting as AMI is a catastrophe in disguise. Prompt checks of TTE and the D-dimer value would bring the hidden diagnosis of acute aortic dissection more to the forefront.
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