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Updated: Jun 20, 2026

Preparation of Stable Bicyclic Aziridinium Ions and Their Ring-Opening for the Synthesis of Azaheterocycles
Published on: August 22, 2018
Facile entry into triazole fused heterocycles via sulfamidate derived azido-alkynes
V Sai Sudhir1, N Y Phani Kumar, R B Nasir Baig
1Department of Organic Chemistry, Indian Institute of Science, Bangalore-560012, Karnataka, India.
Abstract:
Direct synthesis of condensed triazoles from diverse sulfamidates by ring opening of sulfamidates with sodium azide followed by one-pot propargylation and cycloaddition furnished title compounds. The methodology in general has been demonstrated on diverse sulfamidates derived from amino acids, amino acid derivatives, and carbohydrates to obtain diverse triazole fused scaffolds. In one example, a condensed triazole containing amino acid has been synthesized by ring opening of a sulfamidate derivative with propargyl amine.
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