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Updated: Jun 20, 2026

Refined Murine Model of Idiopathic Pulmonary Fibrosis

Refined Murine Model of Idiopathic Pulmonary Fibrosis

Published on: June 17, 2025

Pulmonary hyalinizing granuloma.

Zhao-lin Xu¹, Drew Bethune, Daria Manos

¹Department of Pathology, Queen Elizabeth II Health Sciences Centre and Dalhousie University, Halifax, Nova Scotia, Canada B3H 1V8. zxu3@dal.ca

Beijing Da Xue Xue Bao. Yi Xue Ban = Journal of Peking University. Health Sciences

|September 4, 2009

Summary

Pulmonary hyalinizing granuloma presents with diverse clinical and pathologic features, often associated with other conditions. It is best understood as a clinicopathologic entity rather than a distinct disease.

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Last Updated: Jun 20, 2026

Refined Murine Model of Idiopathic Pulmonary Fibrosis

Refined Murine Model of Idiopathic Pulmonary Fibrosis

Published on: June 17, 2025

Area of Science:

Pulmonology
Pathology
Radiology

Background:

Pulmonary hyalinizing granuloma (PHG) is a rare condition with varied presentations.
Understanding its diverse clinical and pathological spectrum is crucial for diagnosis.

Observation:

Reviewed three institutional cases and English literature on PHG.
Observed concurrent histoplasmosis, lung masses resembling carcinoma, and plaque-like lesions.
Noted lymphocytic infiltration and proliferation in all cases.

Findings:

PHG exhibits a wide range of clinical presentations, radiologic findings, and histological features.
Associated conditions such as histoplasmosis were noted.
Lymphocytic infiltration is a common histological finding.

Implications:

PHG is considered a clinicopathologic entity due to its varied manifestations.
Diagnosis requires integrating clinical, radiological, and pathological data.
Further research may clarify its pathogenesis and relationship to other disorders.