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Related Experiment Video

Updated: Jun 20, 2026

Next Generation Sequencing for the Detection of Actionable Mutations in Solid and Liquid Tumors
11:15

Next Generation Sequencing for the Detection of Actionable Mutations in Solid and Liquid Tumors

Published on: September 20, 2016

Molecular diagnostics of hematologic malignancies.

Anne Avery1

  • 1Department of Microbiology, Immunology and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80523, USA. Anne.avery@colostate.edu

Topics in Companion Animal Medicine
|September 8, 2009
PubMed
Summary

Molecular diagnostics improve canine lymphoma and leukemia diagnosis when conventional methods fail. Tests for gene mutations and lymphocyte clonality aid in resolving ambiguous cases and research questions.

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Last Updated: Jun 20, 2026

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Area of Science:

  • Veterinary Hematology
  • Molecular Diagnostics
  • Oncology

Background:

  • Hematologic malignancies like lymphoma and leukemia present diverse clinical signs.
  • Conventional diagnostic methods can be insufficient for definitive diagnosis in some canine cases.
  • Molecular techniques offer advanced tools for resolving diagnostic ambiguities.

Purpose of the Study:

  • To discuss the utility of molecular diagnostic testing in veterinary hematology.
  • To highlight specific molecular tests for canine lymphoma, leukemia, and mast cell tumors.
  • To emphasize the role of molecular methods in research and clinical practice.

Main Methods:

  • Detection of c-kit gene mutations in mast cell tumors.
  • Identification of the bcr-abl fusion gene in myelogenous leukemias.
  • Assessment of lymphocyte population clonality for lymphoma and leukemia diagnosis.

Main Results:

  • Molecular tests can accurately identify specific genetic alterations associated with canine cancers.
  • Clonality assessment effectively aids in diagnosing and monitoring lymphoid malignancies.
  • Polymerase chain reaction (PCR)-based methods provide sensitive detection for research applications.

Conclusions:

  • Molecular diagnostic testing is crucial for resolving challenging cases of canine hematologic malignancies.
  • These advanced methods enhance diagnostic accuracy and monitoring capabilities.
  • Molecular techniques expand the scope of research in veterinary oncology.