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Updated: Jun 20, 2026
09:33
3D Imaging of PDL Collagen Fibers during Orthodontic Tooth Movement in Mandibular Murine Model
Published on: April 15, 2021
Compressive force induces VEGF production in periodontal tissues
A Miyagawa1, M Chiba, H Hayashi
1Division of Oral Dysfunction Science, Department of Oral Health and Development Sciences, Graduate School of Dentistry, Tohoku University, 4-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan.
Journal of Dental Research
|September 8, 2009
Summary
Compressive force during orthodontic tooth movement stimulates vascular endothelial growth factor (VEGF) production in periodontal ligament (PDL) cells. This promotes blood vessel formation, aiding tissue remodeling.
Area of Science:
- Biomedical Engineering
- Cell Biology
- Orthodontics
Background:
- Periodontal ligament (PDL) vascularization is crucial for tissue remodeling during orthodontic tooth movement.
- Vascular endothelial growth factor (VEGF) is a key mediator of angiogenesis.
Purpose of the Study:
- To investigate the role of compressive force in inducing VEGF production and angiogenesis in PDL.
- To examine VEGF localization in rat periodontal tissues during experimental tooth movement.
- To assess the effects of compressive force on human PDL cells in vitro.
Main Methods:
- In vivo study of VEGF localization in rat periodontal tissues during experimental tooth movement.
- In vitro study of human PDL cells subjected to continuous compressive force.
- Analysis of VEGF mRNA expression, protein production, and angiogenic activity (tube formation).
Main Results:
- PDL cells near compressed bone showed significant VEGF immunoreactivity.
- Compressive force increased VEGF mRNA expression and protein production in PDL cells.
- Conditioned medium from compressed PDL cells promoted blood vessel tube formation.
Conclusions:
- Continuous compressive force enhances VEGF production and angiogenic activity in PDL cells.
- This VEGF-mediated angiogenesis likely contributes to periodontal tissue remodeling during orthodontic tooth movement.
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