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A Facile and Efficient Approach for the Production of Reversible Disulfide Cross-linked Micelles
Published on: December 23, 2016
Cyclodextrin complexation for affinity-based antibiotic delivery
Thimma Reddy Thatiparti1, Horst A von Recum
1Biomedical Engineering, Case Western Reserve University, 10900 Euclid Ave., Wickenden 220, Ohio, USA.
Macromolecular Bioscience
|September 10, 2009
Summary
Novel beta-cyclodextrin (CD) hydrogels offer controlled antibiotic release. These CD-based drug delivery systems show slower, more linear drug release compared to dextrose gels due to affinity-based complexation.
Area of Science:
- Biomaterials Science
- Drug Delivery Systems
- Polymer Chemistry
Background:
- Drug delivery systems require precise control over release kinetics for therapeutic efficacy.
- Cyclodextrins (CDs) are known for their ability to form inclusion complexes, offering potential for tailored drug interactions.
- Hydrogels provide a versatile matrix for encapsulating and releasing therapeutic agents.
Purpose of the Study:
- To develop novel beta-cyclodextrin (CD)-based hydrogels for drug delivery applications.
- To investigate the influence of crosslinker type and concentration on gel properties and drug release.
- To compare the drug release profiles of CD-based hydrogels with conventional dextrose hydrogels.
Main Methods:
- Synthesis and optimization of beta-cyclodextrin polymer hydrogels.
- Characterization using FTIR, SEM, and XRD.
- In vitro swelling, loading efficiency, and drug release studies with model antibiotics (rifampin, novobiocin, vancomycin).
Main Results:
- CD-based hydrogels demonstrated slower and more linear release of antibiotics compared to dextrose hydrogels.
- The release profile was influenced by the affinity between the drug and cyclodextrin, with smaller, hydrophobic drugs showing greater modification.
- Successful loading and controlled release of three model antibiotics were achieved.
Conclusions:
- Affinity-based complexation mechanisms within CD-based hydrogels enable prolonged and linear drug release.
- These hydrogels offer an advantage over purely diffusion-controlled systems for achieving sustained therapeutic levels.
- The developed CD-based hydrogels show promise as advanced drug delivery platforms.
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