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Updated: Jun 20, 2026

Tracking Drug-induced Changes in Receptor Post-internalization Trafficking by Colocalizational Analysis
Published on: July 3, 2015
Receptor trafficking induced by mu-opioid-receptor phosphorylation
Yan Zhang1, Wei Xiong, Xiaojing Lin
1Laboratory of Neurobiology, College of Life Sciences, Peking University, Beijing 100871, China. yanzhang@pku.edu.cn
Abstract:
Opiates, including morphine, are widely used drugs for antinociception in clinics. Prolonged treatments of opioids induce both tolerance and dependence, which are the major side effects of opioid therapy. One of the mechanisms for the development of tolerance and dependence is implicated to be opioid-receptor trafficking. Here we review the current understandings of opioid-receptor phosphorylation, endocytosis and desensitization after repeated agonist treatments. Also, the role of G-protein coupled receptor kinases in opioid-receptor phosphorylation is discussed. How to associate these observations to physiological and behavioral changes in animal models and clinics is still under investigation.
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