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Alternative I-D exchange reaction on pyrimidine and purine nuclei mediated by tributyltin hydride using THF-d8 as a
Tomonobu Mutsumi1, Kazuo Maruhashi, Yasunari Monguchi
1Chemical Technology Laboratory, Taiho Pharmaceutical Co, Ltd, Kodama-gun, Saitama 367-0241, Japan. t-mutsumi@taiho.co.jp
Abstract:
A novel method for the regioselective deuteration of pyrimidine and purine rings mediated by Bu(3)SnH using THF-d(8) as a deuterium source on the basis of a radical reaction was developed.
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