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Building addressable libraries: a site-selective click-reaction strategy for rapidly assembling mass spectrometry

Jennifer L Bartels1, Peng Lu, Amy Walker

  • 1Department of Chemistry, Washington University in St. Louis, St. Louis, MO 63130, USA.

Chemical Communications (Cambridge, England)
|September 16, 2009
PubMed

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Maxam-Gilbert Sequencing01:05

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In the same year as the discovery of the Sanger sequencing method, another group of scientists, Allan Maxam and Walter Gilbert, demonstrated their chemical-cleavage method for DNA sequencing. The Maxam-Gilbert method relies on using different chemicals that can cleave the DNA sequence at specific sites, the separation of resulting DNA fragments of variable size using electrophoresis, and deciphering the DNA sequence from the resulting gel bands.
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