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Measurement of Tissue Oxygenation Using Near-Infrared Spectroscopy in Patients Undergoing Hemodialysis
Published on: October 2, 2020
Complementary parameter for dialysis monitoring based on UV absorbance
Fredrik Uhlin1, Jonas Pettersson, Anders Fernström
1Department of Nephrology, University Hospital, Linköping, Sweden. fredrik.uhlin@lio.se
Hemodialysis International. International Symposium on Home Hemodialysis
|September 18, 2009
Summary
A new optical monitoring method using the area under the UV-absorbance curve (AUCa) shows strong correlation with total solute removal during hemodialysis, offering a complementary measure for dialysis dose estimation.
Area of Science:
- Nephrology
- Biomedical Engineering
- Analytical Chemistry
Background:
- Current methods for estimating dialysis dose, like Kt/V(urea), can be prone to errors from flow variations.
- There is a need for reliable on-line monitoring parameters to accurately assess solute removal during hemodialysis.
Purpose of the Study:
- To introduce and evaluate a new on-line monitoring parameter, the area under the UV-absorbance curve (AUCa), for assessing total solute removal during hemodialysis.
- To investigate the correlation between AUCa and the total removal of key solutes (urea, urate, creatinine, phosphate).
Main Methods:
- Fifteen patients undergoing hemodialysis were monitored using UV absorbance at 297 nm.
- Spent dialysate was analyzed for solute concentrations, serving as the reference method.
- The area under the UV-absorbance curve (AUCa) was calculated and compared with the total amount of removed solutes.
Main Results:
- Strong correlations were observed between AUCa and the total removal of urea, urate, creatinine, and phosphate during individual hemodialysis treatments.
- A less strong correlation was found when analyzing data from all 15 patients collectively.
Conclusions:
- The area under the UV-absorbance curve (AUCa) shows promise as a complementary on-line monitoring parameter for estimating total solute removal in hemodialysis.
- AUCa may help improve the accuracy and reliability of dialysis dose assessment, complementing existing methods like Kt/V(urea).
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