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Updated: Jun 20, 2026

Multimodal Analytical Platform on a Multiplexed Surface Plasmon Resonance Imaging Chip for the Analysis of Extracellular Vesicle Subsets
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Multilayer system for a high-precision surface plasmon resonance sensor.

K Matsubara, S Kawata, S Minami

    Optics Letters
    |September 18, 2009
    PubMed
    Summary
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    This study introduces a multilayer surface plasmon resonance (SPR) system for enhanced chemical sensing. The novel design significantly reduces absorption peak widths, improving refractive index measurement resolution for high-precision applications.

    Area of Science:

    • Optoelectronics
    • Nanotechnology
    • Chemical Sensing

    Background:

    • Surface Plasmon Resonance (SPR) is a label-free optical technique used for detecting changes in refractive index.
    • Conventional SPR sensors, often based on the Kretschmann geometry, face limitations in resolution due to absorption peak width.
    • High-precision chemical sensing requires improved resolution in refractive index measurements.

    Purpose of the Study:

    • To design and demonstrate a multilayer SPR system for enhanced chemical sensor applications.
    • To reduce the absorption peak width in SPR measurements for higher resolution.
    • To investigate the impact of an additional layer on SPR performance.

    Main Methods:

    • Utilized a multilayer system by adding a layer to the conventional Kretschmann geometry.

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    Determination of the Excitation and Coupling Rates Between Light Emitters and Surface Plasmon Polaritons
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    Multimodal Analytical Platform on a Multiplexed Surface Plasmon Resonance Imaging Chip for the Analysis of Extracellular Vesicle Subsets
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    Determination of the Excitation and Coupling Rates Between Light Emitters and Surface Plasmon Polaritons
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    Determination of the Excitation and Coupling Rates Between Light Emitters and Surface Plasmon Polaritons

    Published on: July 21, 2018

  • Employed Fresnel's formulas and multiple-reflectance theory for theoretical calculations.
  • Measured the angular distribution of reflectance from a thin metal film in contact with a sample.
  • Main Results:

    • Achieved significant reduction in absorption peak widths, approximately one third of conventional Kretschmann geometry.
    • Demonstrated that optimizing the thickness of the additional layer is crucial for peak width reduction.
    • Experimental results validated the feasibility and effectiveness of the proposed multilayer SPR system.

    Conclusions:

    • The developed multilayer SPR system offers a pathway to significantly enhance the resolution of refractive index measurements.
    • This advancement holds promise for developing more sensitive and precise chemical sensors.
    • The findings provide a foundation for further optimization of SPR-based sensing technologies.